node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_1095 | Aave_2087 | Aave_1095 | Aave_2087 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 0.414 |
Aave_1095 | Aave_2191 | Aave_1095 | Aave_2191 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 0.414 |
Aave_1095 | Aave_3111 | Aave_1095 | Aave_3111 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | 0.863 |
Aave_1095 | Aave_3833 | Aave_1095 | Aave_3833 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | Pyruvate dehydrogenase (cytochrome); PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: xcb:XC_0216 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 0.956 |
Aave_1095 | ilvC | Aave_1095 | Aave_3110 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.471 |
Aave_1095 | leuA | Aave_1095 | Aave_0019 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.839 |
Aave_1095 | leuA-2 | Aave_1095 | Aave_3108 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.839 |
Aave_1095 | leuB | Aave_1095 | Aave_1221 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.414 |
Aave_1095 | leuC | Aave_1095 | Aave_1223 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.815 |
Aave_1095 | leuD | Aave_1095 | Aave_1222 | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.825 |
Aave_2087 | Aave_1095 | Aave_2087 | Aave_1095 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 0.414 |
Aave_2087 | Aave_2191 | Aave_2087 | Aave_2191 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 0.900 |
Aave_2087 | Aave_3111 | Aave_2087 | Aave_3111 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | 0.971 |
Aave_2087 | ilvC | Aave_2087 | Aave_3110 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.774 |
Aave_2087 | leuA | Aave_2087 | Aave_0019 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.625 |
Aave_2087 | leuA-2 | Aave_2087 | Aave_3108 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.679 |
Aave_2087 | leuC | Aave_2087 | Aave_1223 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.876 |
Aave_2087 | leuD | Aave_2087 | Aave_1222 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.838 |
Aave_2191 | Aave_1095 | Aave_2191 | Aave_1095 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rfr:Rfer_1424 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+). | 0.414 |
Aave_2191 | Aave_2087 | Aave_2191 | Aave_2087 | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | KEGG: rso:RSp1612 probable tartrate dehydrogenase oxidoreductase protein; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 0.900 |