node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_2248 | Aave_2263 | Aave_2248 | Aave_2263 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.681 |
Aave_2248 | Aave_3111 | Aave_2248 | Aave_3111 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | 0.645 |
Aave_2248 | Aave_3112 | Aave_2248 | Aave_3112 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pol:Bpro_2317 acetolactate synthase, large subunit, biosynthetic type. | 0.794 |
Aave_2248 | ilvC | Aave_2248 | Aave_3110 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.798 |
Aave_2248 | leuA-2 | Aave_2248 | Aave_3108 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.529 |
Aave_2248 | leuB | Aave_2248 | Aave_1221 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.636 |
Aave_2248 | leuC | Aave_2248 | Aave_1223 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.691 |
Aave_2248 | leuD | Aave_2248 | Aave_1222 | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.687 |
Aave_2263 | Aave_2248 | Aave_2263 | Aave_2248 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.681 |
Aave_2263 | Aave_3111 | Aave_2263 | Aave_3111 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | 0.995 |
Aave_2263 | Aave_3112 | Aave_2263 | Aave_3112 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pol:Bpro_2317 acetolactate synthase, large subunit, biosynthetic type. | 0.924 |
Aave_2263 | Aave_3759 | Aave_2263 | Aave_3759 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bja:bll0378 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.736 |
Aave_2263 | ilvC | Aave_2263 | Aave_3110 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.981 |
Aave_2263 | ilvD | Aave_2263 | Aave_1506 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | KEGG: reu:Reut_A2432 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.645 |
Aave_2263 | leuA-2 | Aave_2263 | Aave_3108 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.896 |
Aave_2263 | leuB | Aave_2263 | Aave_1221 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.949 |
Aave_2263 | leuC | Aave_2263 | Aave_1223 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.555 |
Aave_2263 | leuD | Aave_2263 | Aave_1222 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.555 |
Aave_3111 | Aave_2248 | Aave_3111 | Aave_2248 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | L-arabinonate dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bcn:Bcen_5215 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.645 |
Aave_3111 | Aave_2263 | Aave_3111 | Aave_2263 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rfr:Rfer_0882 thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.995 |