node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_3316 | htpX | Aave_3316 | Aave_4316 | PFAM: protein of unknown function UPF0005; KEGG: rfr:Rfer_2776 protein of unknown function UPF0005; Belongs to the BI1 family. | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.475 |
Aave_3605 | htpX | Aave_3605 | Aave_4316 | KEGG: pol:Bpro_1298 hypothetical protein. | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.455 |
Aave_4317 | Aave_4318 | Aave_4317 | Aave_4318 | KEGG: pol:Bpro_1031 putative transmembrane protein. | PFAM: protein of unknown function DUF88; KEGG: pol:Bpro_1025 protein of unknown function DUF88. | 0.859 |
Aave_4317 | htpX | Aave_4317 | Aave_4316 | KEGG: pol:Bpro_1031 putative transmembrane protein. | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.669 |
Aave_4317 | pyrC | Aave_4317 | Aave_4319 | KEGG: pol:Bpro_1031 putative transmembrane protein. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.860 |
Aave_4318 | Aave_4317 | Aave_4318 | Aave_4317 | PFAM: protein of unknown function DUF88; KEGG: pol:Bpro_1025 protein of unknown function DUF88. | KEGG: pol:Bpro_1031 putative transmembrane protein. | 0.859 |
Aave_4318 | htpX | Aave_4318 | Aave_4316 | PFAM: protein of unknown function DUF88; KEGG: pol:Bpro_1025 protein of unknown function DUF88. | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.660 |
Aave_4318 | pyrC | Aave_4318 | Aave_4319 | PFAM: protein of unknown function DUF88; KEGG: pol:Bpro_1025 protein of unknown function DUF88. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. | 0.864 |
Aave_4561 | dnaJ | Aave_4561 | Aave_1225 | TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.725 |
Aave_4561 | groS | Aave_4561 | Aave_0946 | TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.615 |
Aave_4561 | grpE | Aave_4561 | Aave_1227 | TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.837 |
Aave_4561 | htpX | Aave_4561 | Aave_4316 | TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.566 |
dnaJ | Aave_4561 | Aave_1225 | Aave_4561 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: pol:Bpro_4628 thioredoxin. | 0.725 |
dnaJ | ftsH | Aave_1225 | Aave_2617 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.712 |
dnaJ | groS | Aave_1225 | Aave_0946 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.833 |
dnaJ | grpE | Aave_1225 | Aave_1227 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.984 |
dnaJ | htpX | Aave_1225 | Aave_4316 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein; PFAM: peptidase M48, Ste24p; HtpX domain protein; KEGG: pol:Bpro_1032 peptidase M48, Ste24p; Metallo peptidase; MEROPS family M48B; Belongs to the peptidase M48B family. | 0.503 |
ftsH | dnaJ | Aave_2617 | Aave_1225 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.712 |
ftsH | groS | Aave_2617 | Aave_0946 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.462 |
ftsH | grpE | Aave_2617 | Aave_1227 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.655 |