node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADC48733.1 | coaE | BpOF4_03335 | BpOF4_03315 | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.457 |
ADC48733.1 | hflK/C | BpOF4_03335 | BpOF4_03340 | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | Stomatin, Prohibitn, Flotillin HflK/C domain protein; HflC and HflK could encode or regulate a protease. | 0.860 |
ADC48733.1 | mutM | BpOF4_03335 | BpOF4_03325 | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.565 |
ADC48733.1 | polA | BpOF4_03335 | BpOF4_03330 | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.653 |
ADC48733.1 | ytaF | BpOF4_03335 | BpOF4_03320 | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | Membrane protein involved in sporulation; Probably functions as a manganese efflux pump. | 0.473 |
ADC51801.1 | dnaQ/dinG | BpOF4_18810 | BpOF4_15620 | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | Bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; 3'-5' exonuclease. | 0.715 |
ADC51801.1 | mutM | BpOF4_18810 | BpOF4_03325 | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.630 |
ADC51801.1 | nth | BpOF4_18810 | BpOF4_15665 | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.403 |
ADC51801.1 | polA | BpOF4_18810 | BpOF4_03330 | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.580 |
coaE | ADC48733.1 | BpOF4_03315 | BpOF4_03335 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Stomatin, prohibitin, flotillin, Hf1K/C domain family protein; HflC and HflK could regulate a protease. | 0.457 |
coaE | hflK/C | BpOF4_03315 | BpOF4_03340 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Stomatin, Prohibitn, Flotillin HflK/C domain protein; HflC and HflK could encode or regulate a protease. | 0.457 |
coaE | mutM | BpOF4_03315 | BpOF4_03325 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.986 |
coaE | nth | BpOF4_03315 | BpOF4_15665 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.445 |
coaE | polA | BpOF4_03315 | BpOF4_03330 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.824 |
coaE | ytaF | BpOF4_03315 | BpOF4_03320 | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Membrane protein involved in sporulation; Probably functions as a manganese efflux pump. | 0.865 |
dnaB | mutM | BpOF4_03290 | BpOF4_03325 | DNA replication protein DnaB; COG3611 Replication initiation/membrane attachment protein. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.562 |
dnaB | polA | BpOF4_03290 | BpOF4_03330 | DNA replication protein DnaB; COG3611 Replication initiation/membrane attachment protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.426 |
dnaQ/dinG | ADC51801.1 | BpOF4_15620 | BpOF4_18810 | Bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; 3'-5' exonuclease. | COG0258 5'-3' exonuclease (including N-terminal domain of PolI). | 0.715 |
dnaQ/dinG | mutM | BpOF4_15620 | BpOF4_03325 | Bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; 3'-5' exonuclease. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.612 |
dnaQ/dinG | nth | BpOF4_15620 | BpOF4_15665 | Bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; 3'-5' exonuclease. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.495 |