node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADC49249.1 | ADC51004.1 | BpOF4_05935 | BpOF4_14775 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG0213 Thymidine phosphorylase. | 0.915 |
ADC49249.1 | cdd | BpOF4_05935 | BpOF4_13680 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.935 |
ADC49249.1 | comEB | BpOF4_05935 | BpOF4_13285 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Late competence operon required for DNA binding and uptake; COG2131 Deoxycytidylate deaminase. | 0.904 |
ADC49249.1 | punA | BpOF4_05935 | BpOF4_14760 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.910 |
ADC49249.1 | punA-2 | BpOF4_05935 | BpOF4_14770 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.910 |
ADC49249.1 | tdk | BpOF4_05935 | BpOF4_06980 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG1435 Thymidine kinase. | 0.920 |
ADC49249.1 | thyA | BpOF4_05935 | BpOF4_05005 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.916 |
ADC49249.1 | tmk | BpOF4_05935 | BpOF4_08100 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.925 |
ADC49249.1 | ushA | BpOF4_05935 | BpOF4_16655 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Protein ushA precursor (two S-layer domains, UDP-sugar hydrolase, 5'-nucleotidase); COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.928 |
ADC49249.1 | yunD | BpOF4_05935 | BpOF4_05020 | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Putative nuclease/nucleotidase/phosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.928 |
ADC51004.1 | ADC49249.1 | BpOF4_14775 | BpOF4_05935 | COG0213 Thymidine phosphorylase. | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.915 |
ADC51004.1 | cdd | BpOF4_14775 | BpOF4_13680 | COG0213 Thymidine phosphorylase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.993 |
ADC51004.1 | punA | BpOF4_14775 | BpOF4_14760 | COG0213 Thymidine phosphorylase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.956 |
ADC51004.1 | punA-2 | BpOF4_14775 | BpOF4_14770 | COG0213 Thymidine phosphorylase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.977 |
ADC51004.1 | tdk | BpOF4_14775 | BpOF4_06980 | COG0213 Thymidine phosphorylase. | COG1435 Thymidine kinase. | 0.943 |
ADC51004.1 | thyA | BpOF4_14775 | BpOF4_05005 | COG0213 Thymidine phosphorylase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.424 |
ADC51004.1 | ushA | BpOF4_14775 | BpOF4_16655 | COG0213 Thymidine phosphorylase. | Protein ushA precursor (two S-layer domains, UDP-sugar hydrolase, 5'-nucleotidase); COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.903 |
ADC51004.1 | yunD | BpOF4_14775 | BpOF4_05020 | COG0213 Thymidine phosphorylase. | Putative nuclease/nucleotidase/phosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.903 |
cdd | ADC49249.1 | BpOF4_13680 | BpOF4_05935 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | SLH domain-containing esterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.935 |
cdd | ADC51004.1 | BpOF4_13680 | BpOF4_14775 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | COG0213 Thymidine phosphorylase. | 0.993 |