node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD20064.1 | grpE | Bphyt_5718 | Bphyt_0736 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.509 |
ACD20064.1 | hslU | Bphyt_5718 | Bphyt_0342 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.438 |
ACD20064.1 | hslV | Bphyt_5718 | Bphyt_0343 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.472 |
ACD20064.1 | htpG | Bphyt_5718 | Bphyt_1216 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.555 |
ACD20064.1 | lon-2 | Bphyt_5718 | Bphyt_5717 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.816 |
ACD20649.1 | ftsH | Bphyt_6322 | Bphyt_2862 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.422 |
ACD20649.1 | groL | Bphyt_6322 | Bphyt_0864 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.815 |
ACD20649.1 | grpE | Bphyt_6322 | Bphyt_0736 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.885 |
ACD20649.1 | hslU | Bphyt_6322 | Bphyt_0342 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.703 |
ACD20649.1 | hslV | Bphyt_6322 | Bphyt_0343 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.551 |
ACD20649.1 | htpG | Bphyt_6322 | Bphyt_1216 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.943 |
ACD20649.1 | lon-2 | Bphyt_6322 | Bphyt_5717 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: bxe:Bxe_B2345 putative DnaJ chaperone protein. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.540 |
clpX | ftsH | Bphyt_1907 | Bphyt_2862 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.772 |
clpX | groL | Bphyt_1907 | Bphyt_0864 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.608 |
clpX | grpE | Bphyt_1907 | Bphyt_0736 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.422 |
clpX | hslU | Bphyt_1907 | Bphyt_0342 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.483 |
clpX | hslV | Bphyt_1907 | Bphyt_0343 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.511 |
clpX | lon-2 | Bphyt_1907 | Bphyt_5717 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.551 |
dnaJ | ftsH | Bphyt_0738 | Bphyt_2862 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.674 |
dnaJ | groL | Bphyt_0738 | Bphyt_0864 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.917 |