node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_0936 | Spea_1802 | Spea_0936 | Spea_1802 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | 0.654 |
Spea_0936 | Spea_1803 | Spea_0936 | Spea_1803 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | 0.430 |
Spea_0936 | bioB | Spea_0936 | Spea_1801 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.876 |
Spea_0936 | bioD | Spea_0936 | Spea_1804 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.871 |
Spea_0936 | birA | Spea_0936 | Spea_0168 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.495 |
Spea_0936 | kbl | Spea_0936 | Spea_0107 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.651 |
Spea_0936 | thiE | Spea_0936 | Spea_2382 | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.424 |
Spea_1329 | bioB | Spea_1329 | Spea_1801 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pin:Ping_2637 methyltransferase type 12. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.608 |
Spea_1329 | bioD | Spea_1329 | Spea_1804 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pin:Ping_2637 methyltransferase type 12. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.423 |
Spea_1802 | Spea_0936 | Spea_1802 | Spea_0936 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.654 |
Spea_1802 | Spea_1803 | Spea_1802 | Spea_1803 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | 0.939 |
Spea_1802 | bioA | Spea_1802 | Spea_1800 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.988 |
Spea_1802 | bioB | Spea_1802 | Spea_1801 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.940 |
Spea_1802 | bioD | Spea_1802 | Spea_1804 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.983 |
Spea_1802 | birA | Spea_1802 | Spea_0168 | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.492 |
Spea_1803 | Spea_0936 | Spea_1803 | Spea_0936 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | PFAM: aminotransferase class-III; KEGG: slo:Shew_0966 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.430 |
Spea_1803 | Spea_1802 | Spea_1803 | Spea_1802 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sbm:Shew185_1752 8-amino-7-oxononanoate synthase. | 0.939 |
Spea_1803 | bioA | Spea_1803 | Spea_1800 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.609 |
Spea_1803 | bioB | Spea_1803 | Spea_1801 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.944 |
Spea_1803 | bioD | Spea_1803 | Spea_1804 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: she:Shewmr4_2357 biotin biosynthesis protein BioC. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.979 |