node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_0029 | Spea_0544 | Spea_0029 | Spea_0544 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | 0.679 |
Spea_0029 | rsmF | Spea_0029 | Spea_1927 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Putative RNA methylase, NOL1/NOP2/sun family; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.436 |
Spea_0029 | thiI | Spea_0029 | Spea_2986 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.906 |
Spea_0544 | Spea_0029 | Spea_0544 | Spea_0029 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.679 |
Spea_0544 | Spea_2381 | Spea_0544 | Spea_2381 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | 0.644 |
Spea_0544 | iscS | Spea_0544 | Spea_1488 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.944 |
Spea_0544 | rplK | Spea_0544 | Spea_0173 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.614 |
Spea_0544 | rsmF | Spea_0544 | Spea_1927 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Putative RNA methylase, NOL1/NOP2/sun family; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.417 |
Spea_0544 | thiE | Spea_0544 | Spea_2382 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.526 |
Spea_0544 | thiI | Spea_0544 | Spea_2986 | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.997 |
Spea_2006 | thiI | Spea_2006 | Spea_2986 | PFAM: Fmu (Sun) domain protein; KEGG: son:SO_2215 sun protein, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.817 |
Spea_2381 | Spea_0544 | Spea_2381 | Spea_0544 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | 0.644 |
Spea_2381 | iscS | Spea_2381 | Spea_1488 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.729 |
Spea_2381 | thiE | Spea_2381 | Spea_2382 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.989 |
Spea_2381 | thiG | Spea_2381 | Spea_2379 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.992 |
Spea_2381 | thiI | Spea_2381 | Spea_2986 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.940 |
Spea_2960 | thiI | Spea_2960 | Spea_2986 | PFAM: Fmu (Sun) domain protein; KEGG: sfr:Sfri_1209 Fmu (Sun) domain protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.817 |
iscS | Spea_0544 | Spea_1488 | Spea_0544 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | PFAM: aminotransferase class V; beta-lactamase domain protein; Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V. | 0.944 |
iscS | Spea_2381 | Spea_1488 | Spea_2381 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: shn:Shewana3_1938 UBA/ThiF-type NAD/FAD binding protein. | 0.729 |
iscS | thiI | Spea_1488 | Spea_2986 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.985 |