STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lldD2FMN-dependent dehydrogenase, Reaction: (S)-lactate + 2 ferricytochrome c <=> pyruvate + 2 ferrocytochrome c + 2 H+; cytochrome. (390 aa)    
Predicted Functional Partners:
dld
D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.
 
 0.943
Dshi_0826
Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH.
  
 
 0.936
maeB
NADP-dependent malic enzyme; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding KEGG: sit:TM1040_2877 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)., phosphate acetyltransferase; NADP-ME.
    
 0.936
dld1
D-lactate dehydrogenase; Catalyzes the stereospecific oxidation of D-lactate to pyruvate; cytochrome.
 
 0.929
pykA
KEGG: rsp:RSP_1766 pyruvate kinase TIGRFAM: pyruvate kinase PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; high swissprot; Belongs to the pyruvate kinase family.
  
 0.928
lldD1
Swiss-Prot: P33232- L-lactate dehydrogenase [cytochrome] lldD PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase KEGG: sit:TM1040_2026 L-lactate dehydrogenase (cytochrome).
  
  
 
0.918
Dshi_2485
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 
 0.914
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
   
 
 0.911
Dshi_2401
Swiss-Prot: P22983-Pyruvate, phosphate dikinase TIGR01828: pyruvate, phosphate dikinase PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region KEGG: rde:RD1_1948 pyruvate, phosphate dikinase.
     
 0.911
pdhB2
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
    
 0.908
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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