STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dshi_1119Contains DEAD/H associated domain. (807 aa)    
Predicted Functional Partners:
Dshi_1118
Conserved hypothetical protein.
    0.984
Dshi_2589
DNA ligase; Swiss-Prot: Q9HR35-DNA ligase PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase KEGG: rde:RD1_1817 thermostable DNA ligase.
 
    0.814
Dshi_2587
Hypothetical protein; PFAM: Metallo-beta-lactamase superfamily COG1236: Predicted exonuclease of the beta-lactamase fold involved in RNA processing; related to beta-lactamases.
 
    0.813
Dshi_1117
Thioesterase superfamily protein.
  
    0.776
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.736
Dshi_1120
Conserved hypothetical protein.
       0.712
Dshi_2244
Conserved hypothetical protein; PFAM: protein of unknown function DUF1052 KEGG: jan:Jann_3406 protein of unknown function DUF1052.
  
     0.691
radA
Putative DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
    0.557
Dshi_1121
Peptidase A24A prepilin type IV.
       0.554
Dshi_1122
Tetratricopeptide region.
       0.551
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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