node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | fmt | Dshi_1283 | Dshi_0181 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.408 |
fhs | folD | Dshi_1283 | Dshi_1285 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | NADP(+) dependent methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvT2 | Dshi_1283 | Dshi_2682 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Swiss-Prot: P54378-Aminomethyltransferase TIGRFAM: glycine cleavage system T protein PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. | 0.926 |
fhs | glyA1 | Dshi_1283 | Dshi_2113 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.952 |
fhs | glyA2 | Dshi_1283 | Dshi_0821 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.952 |
fhs | metF | Dshi_1283 | Dshi_2080 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | SWISSPROT P0AEZ1: 5,10-methylenetetrahydrofolate reductase; PFAM: PF02219- Methylenetetrahydrofolate reductase; TIGRFAM: TIGR00676 5,10-methylenetetrahydrofolate reductase, prokaryotic form; COG: COG0685 - 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.409 |
fhs | purD | Dshi_1283 | Dshi_2728 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Swiss-Prot: P15640- Phosphoribosylamine--glycine ligase TIGRFAM: phosphoribosylamine--glycine ligase PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.665 |
fhs | purH | Dshi_1283 | Dshi_0358 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rde:RD1_0655 bifunctional purine biosynthesis protein PurH TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; high swissprot to Bifunctional purine biosynthesis protein purH from Brucella suis. | 0.990 |
fhs | purN | Dshi_1283 | Dshi_1888 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.968 |
fhs | purU | Dshi_1283 | Dshi_2111 | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.616 |
fmt | fhs | Dshi_0181 | Dshi_1283 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | 0.408 |
fmt | folD | Dshi_0181 | Dshi_1285 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | NADP(+) dependent methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.977 |
fmt | gcvT2 | Dshi_0181 | Dshi_2682 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Swiss-Prot: P54378-Aminomethyltransferase TIGRFAM: glycine cleavage system T protein PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. | 0.915 |
fmt | glyA1 | Dshi_0181 | Dshi_2113 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
fmt | glyA2 | Dshi_0181 | Dshi_0821 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
fmt | purH | Dshi_0181 | Dshi_0358 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | KEGG: rde:RD1_0655 bifunctional purine biosynthesis protein PurH TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; high swissprot to Bifunctional purine biosynthesis protein purH from Brucella suis. | 0.602 |
fmt | purN | Dshi_0181 | Dshi_1888 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.936 |
folD | fhs | Dshi_1285 | Dshi_1283 | NADP(+) dependent methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Participates in the transfer of one-carbon units; Belongs to the formate--tetrahydrofolate ligase family. | 0.998 |
folD | fmt | Dshi_1285 | Dshi_0181 | NADP(+) dependent methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.977 |
folD | gcvT2 | Dshi_1285 | Dshi_2682 | NADP(+) dependent methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Swiss-Prot: P54378-Aminomethyltransferase TIGRFAM: glycine cleavage system T protein PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. | 0.958 |