STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Dshi_1430This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. (487 aa)    
Predicted Functional Partners:
acsA
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.929
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.929
fadJ
3-hydroxyacyl-CoA dehydrogenase NAD-binding; Multifunctional enzyme: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase, Reaction: (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA + H2O, Reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA; 3-hydroxyacyl-CoA dehydrogenase, Reaction(EC:1.1.1.35):(3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+.
  
 0.925
mmsA
SWISSPROT P28810: Methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: TIGR01722 methylmalonic acid semialdehyde dehydrogenase; PANTHER: PTHR11699:SF27; PFAM: PF00171; PROSITE: PS00070; COG: COG1012 - NAD-dependent aldehyde dehydrogenases.
  
 
 
0.924
adhI
TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein KEGG: sil:SPOA0272 glutathione-dependent formaldehyde dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
 
 0.917
Dshi_0473
TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; high swissprot hit to Alcohol dehydrogenase class-3 from Rhodobacter sphaeroides 2.4.1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
 
 0.917
mmsB
TIGRFAM: TIGR01692 3-hydroxyisobutyrate dehydrogenase; PANTHER: PTHR22981; PROSITE: PS00895; PFAM: PF03446; Gene3D: G3DSA:1.10.1040.10; Belongs to the HIBADH-related family.
 
 
 0.916
ald
PFAM: aldehyde dehydrogenase KEGG: sil:SPO3368 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.916
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
 
 
 0.915
ackA-2
Hypothetical protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
 
 
 0.915
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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