STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Dshi_2114Putative sarcosine oxidase, gamma subunit; SWISSPROT O87386: Sarcosine oxidase subunit alpha; TIGRFAM: TIGR01375 sarcosine oxidase, gamma subunit family, heterotetrameric form; COG: COG4583 - Sarcosine oxidase gamma subunit; PFAM: PF04268: SUPERFAMILY: SSF103025. (176 aa)    
Predicted Functional Partners:
soxA2
SWISSPROT Q46337: Sarcosine oxidase subunit alpha; TIGRFAM: TIGR01372 sarcosine oxidase, alpha subunit family, heterotetrameric form; COG: COG0404 - Glycine cleavage system T protein (aminomethyltransferase); PFAM: PF01571, PF08669, PF07992; Belongs to the GcvT family.
 
 0.999
Dshi_2116
SWISSPROT Q46336: Sarcosine oxidase subunit delta; PFAM: Sarcosine oxidase, delta subunit family; TIGRFAM: TIGR01374; COG: COG4311 - Sarcosine oxidase delta subunit; delta subunit (soxD).
 
 0.999
soxB
SWISSPROT P40875: sarcosine oxidase subunit beta; PFAM: PF01266-FAD dependent oxidoreductase; TIGRFAM: TIGR01373-Sarcosine oxidase, beta subunit, heterotetrameric; COG: COG0665 - Glycine/D-amino acid oxidases (deaminating).
 
 0.994
Dshi_1485
DOMAINS: FAD dependent oxidoreductase, Glycine cleavage T-protein, involved in amine and polyamine degradation; Belongs to the GcvT family.
  
 0.985
Dshi_2967
Bifunctional enzyme involved in glycine degradation; COG: COG0404 - Glycine cleavage system T protein (aminomethyltransferase); PFAM: PF01266, PF01571, PF08669; Belongs to the GcvT family.
  
 0.984
glyA1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.958
Dshi_2264
TIGRFAM: sarcosine oxidase, alpha subunit family (TIGR01372) Swiss-Prot: O87386 - Sarcosine oxidase subunit alpha PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein barrel; alpha subunit family; Belongs to the GcvT family.
 
 
 0.949
Dshi_2126
Creatinase; SWISSPROT P38488: Creatinase; COG: COG0006 - Xaa-Pro aminopeptidase; PFAM: PF00557, PF01321.
  
 
  0.912
gcvP
Decarboxylating glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
 0.911
glyA2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.910
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.