STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa)    
Predicted Functional Partners:
pdhB2
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
pdhC1
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
pdhB1
Pyruvate dehydrogenase E1 component subunit beta; PFAM: Transketolase central region; Transketolase domain protein; high swissprot hit to Pyruvate dehydrogenase E1 component subunit beta from Rickettsia bellii RML369-C; high Ref YP hit to Transketolase central region [Sinorhizobium medicae WSM419]; Transketolase central region.
 0.998
lpdA
SWISSPROT P0A9P0: Dihydrolipoyl dehydrogenase; PFAM: PF00364, PF00070, PF02852, PF07992; PROSITE: PS50968, PS00189, PS00076; PRINTS: PR00945, PR00411, PR00368; TIGRFAM: TIGR01350 dihydrolipoamide dehydrogenase; COG: COG1249 - Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.
 
 0.996
pdhC2
Dihydrolipoamide acetyltransferase; PFAM: alpha/beta hydrolase fold; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; middle swissprot hit to Acetoin dehydrogenase E2 component from Pseudomonas putida; high Ref YP hit to branched-chain alpha-keto acid dehydrogenase subunit E2 from Sinorhizobium medicae WSM419; unsure GC frame plot; pyruvate dehydrogenase E2 component.
 0.993
lpdV
SWISSPROT Q9I1L9: Dihydrolipoyl dehydrogenase; TIGRFAM: TIGR01350; PFAM: PF00070, PF02852, PF07992.
 
 0.987
aceF
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.978
lpd
SWISSPROT P14218: Dihydrolipoyl dehydrogenase; TIGRFAM: TIGR01350 dihydrolipoamide dehydrogenase; COG: COG1249 - Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; PFAM: PF00070, PF02852, PF07992; PRINTS: PR00945, PR00411, PR00368.
 
 0.975
Dshi_0826
Malic protein NAD-binding; Malate decarboxylase, NAD(P) dependent(two forms of the enzyme with different kinetics), Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH.
  
 
 0.964
maeB
NADP-dependent malic enzyme; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding KEGG: sit:TM1040_2877 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)., phosphate acetyltransferase; NADP-ME.
  
 
 0.949
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.