node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dshi_2953 | Dshi_2954 | Dshi_2953 | Dshi_2954 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | 0.999 |
Dshi_2953 | hisA | Dshi_2953 | Dshi_2578 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Swiss-Prot: Q28NK3- 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase PFAM: histidine biosynthesis protein. | 0.924 |
Dshi_2953 | hisB | Dshi_2953 | Dshi_0794 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol-phosphate dehydratase; Histidine metabolism, Reaction: D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + H2O. | 0.941 |
Dshi_2953 | hisD1 | Dshi_2953 | Dshi_0979 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.873 |
Dshi_2953 | hisD2 | Dshi_2953 | Dshi_2034 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.855 |
Dshi_2953 | hisD3 | Dshi_2953 | Dshi_2242 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.818 |
Dshi_2953 | hisE | Dshi_2953 | Dshi_2575 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Swiss-Prot: P06989-Phosphoribosyl-ATP pyrophosphatase PFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.990 |
Dshi_2953 | hisF | Dshi_2953 | Dshi_2576 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.943 |
Dshi_2953 | hisH | Dshi_2953 | Dshi_0795 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.951 |
Dshi_2953 | hisI | Dshi_2953 | Dshi_1515 | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.948 |
Dshi_2954 | Dshi_2953 | Dshi_2954 | Dshi_2953 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
Dshi_2954 | hisA | Dshi_2954 | Dshi_2578 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Swiss-Prot: Q28NK3- 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase PFAM: histidine biosynthesis protein. | 0.905 |
Dshi_2954 | hisB | Dshi_2954 | Dshi_0794 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Imidazoleglycerol-phosphate dehydratase; Histidine metabolism, Reaction: D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + H2O. | 0.905 |
Dshi_2954 | hisD1 | Dshi_2954 | Dshi_0979 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.777 |
Dshi_2954 | hisD2 | Dshi_2954 | Dshi_2034 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.775 |
Dshi_2954 | hisD3 | Dshi_2954 | Dshi_2242 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.775 |
Dshi_2954 | hisE | Dshi_2954 | Dshi_2575 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Swiss-Prot: P06989-Phosphoribosyl-ATP pyrophosphatase PFAM: phosphoribosyl-ATP pyrophosphohydrolase. | 0.990 |
Dshi_2954 | hisF | Dshi_2954 | Dshi_2576 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.904 |
Dshi_2954 | hisH | Dshi_2954 | Dshi_0795 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.898 |
Dshi_2954 | hisI | Dshi_2954 | Dshi_1515 | Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.903 |