STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panCPantothenate synthase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
 0.998
coaX
Putative transcriptional acitvator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
 
 
 0.970
panE
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.942
Dshi_2954
Hypothetical protein; COG: COG3705 - ATP phosphoribosyltransferase involved in histidine biosynthesis; PFAM: PF00587; PANTHER: Histidyl-tRNA-synthetase; related to tRNA synthetase.
  
  
 0.925
Dshi_1366
Aminotransferase class-III; Similar to omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.913
coaBC
Coenzyme A biosynthesis bifunctional protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.912
cmk
Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5-diphosphate (dCDP) in the presence of ATP or GTP, Reaction: ATP + (d)CMP <=> ADP + (d)CDP.
 
    0.911
Dshi_1430
This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor.
     
 0.900
ald
PFAM: aldehyde dehydrogenase KEGG: sil:SPO3368 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
     
 0.900
puuC
PFAM: aldehyde dehydrogenase KEGG: sil:SPO0097 aldehyde dehydrogenase family protein; Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
     
 0.900
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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