STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (289 aa)    
Predicted Functional Partners:
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 0.997
Dshi_1696
alpha-IPM synthetase/homocitrate synthase family transferase; TIGRFAM: TIGR00977 2-isopropylmalate synthase/homocitrate synthase family protein; COG: COG0119; PFAM: PF00682, PF08502; PROSITE: PS00815, PS00816; SUPERFAMILY: SSF110921, SSF51569; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.968
ilvD1
KEGG: rde:RD1_0332 dihydroxy-acid dehydratase TIGRFAM: dihydroxy-acid dehydratase PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Swissprot: high similarity to dihydroxyacid dehydratase from Loktanella vestfoldensis SKA53; Belongs to the IlvD/Edd family.
  
 0.962
Dshi_2566
Putative bifunctional enzyme; PFAM: dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; transketolase / dehydrogenase.
  
 0.946
Dshi_2837
Aminotransferase; Swiss-Prot: P0AB80-Branched-chain-amino-acid aminotransferase PFAM: aminotransferase class IV; class IV.
  
 
 
0.921
metB1
Cystathionine gamma-synthase; PLP-dependent enzyme, Methionine metabolism, Reaction: O4-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate.
   
 0.915
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.913
gsh
Glutamate-cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
   
 
  0.901
Dshi_3469
REFSEQ: putative branched-chain amino acid aminotransferase.
 
    0.880
Dshi_2273
Swiss-Prot: P29365 - Homoserine dehydrogenase PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding KEGG: sil:SPO1734 homoserine dehydrogenase.
  
 
 0.873
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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