node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Glov_0070 | Glov_2671 | Glov_0070 | Glov_2671 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | 0.577 |
Glov_0070 | Glov_2675 | Glov_0070 | Glov_2675 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | 0.935 |
Glov_0070 | folD | Glov_0070 | Glov_0508 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
Glov_0070 | glyA | Glov_0070 | Glov_1932 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
Glov_0070 | purH | Glov_0070 | Glov_2760 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | KEGG: gsu:GSU0609 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.904 |
Glov_0070 | purN | Glov_0070 | Glov_2107 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.994 |
Glov_1933 | glyA | Glov_1933 | Glov_1932 | KEGG: ppd:Ppro_1747 sugar-phosphate isomerases, RpiB/LacA/LacB family; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
Glov_2671 | Glov_0070 | Glov_2671 | Glov_0070 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | 0.577 |
Glov_2671 | Glov_2675 | Glov_2671 | Glov_2675 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | 0.999 |
Glov_2671 | folD | Glov_2671 | Glov_0508 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.688 |
Glov_2671 | gcvH | Glov_2671 | Glov_1599 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
Glov_2671 | gcvH-2 | Glov_2671 | Glov_2673 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
Glov_2671 | gcvPA | Glov_2671 | Glov_2672 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
Glov_2671 | glyA | Glov_2671 | Glov_1932 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.982 |
Glov_2671 | purH | Glov_2671 | Glov_2760 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | KEGG: gsu:GSU0609 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.577 |
Glov_2675 | Glov_0070 | Glov_2675 | Glov_0070 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: cac:CAC2445 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. | 0.935 |
Glov_2675 | Glov_2671 | Glov_2675 | Glov_2671 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gme:Gmet_3152 glycine dehydrogenase subunit 2. | 0.999 |
Glov_2675 | folD | Glov_2675 | Glov_0508 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
Glov_2675 | gcvH | Glov_2675 | Glov_1599 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
Glov_2675 | gcvH-2 | Glov_2675 | Glov_2673 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gme:Gmet_3155 glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |