STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKA-2Cyclin-dependent kinase A-2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (292 aa)    
Predicted Functional Partners:
CKS1
Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family.
   
 0.954
WEE1
Wee1-like protein kinase.
  
0.952
CDC6
Cell division control protein 6 homolog; May be involved in the initiation of DNA replication.
   
 0.937
ORC2
Origin of replication complex subunit 2; Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity); Belongs to the ORC2 family.
   
 0.917
CDKD-1
Cyclin-dependent kinase D-1; CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.
  
0.911
CYCD3-2
Cyclin-D3-2; Belongs to the cyclin family. Cyclin D subfamily.
   
 0.908
CYCB2-1
Cyclin-B2-1; Involved in the control of the cell cycle at the G2/M (mitosis) transition. May activate CDKB2-1 kinase.
   
 0.903
CYCB2-2
Cyclin-B2-2; Involved in the control of the cell cycle at the G2/M (mitosis) transition. May associate to CDKB2-1 and activate CDKB2-1 kinase activity to promote cell division; Belongs to the cyclin family. Cyclin AB subfamily.
   
 0.900
P0535F09.39
Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Seems to play a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity); Belongs to the PI3/PI4-kinase family. ATM subfamily.
    
 0.900
CYCD2-2
Cyclin-D2-2; Belongs to the cyclin family. Cyclin D subfamily.
   
 0.899
Your Current Organism:
Oryza sativa Japonica
NCBI taxonomy Id: 39947
Other names: Japanese rice, Japonica rice, O. sativa Japonica Group, Oryza sativa (japonica cultivar-group), Oryza sativa Japonica Group, Oryza sativa subsp. japonica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.