node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0255 | Spro_1830 | Spro_0255 | Spro_1830 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | KEGG: pla:Plav_2905 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aminotransferase class I and II. | 0.913 |
Spro_0255 | Spro_2904 | Spro_0255 | Spro_2904 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.901 |
Spro_0255 | cysG1 | Spro_0255 | Spro_0817 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.868 |
Spro_0255 | cysG2 | Spro_0255 | Spro_4598 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.881 |
Spro_0255 | hemA | Spro_0255 | Spro_1989 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.869 |
Spro_0255 | hemC | Spro_0255 | Spro_0178 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
Spro_0255 | hemE | Spro_0255 | Spro_0287 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.741 |
Spro_0255 | hemL | Spro_0255 | Spro_0781 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase. | 0.993 |
Spro_0342 | Spro_3427 | Spro_0342 | Spro_3427 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase. | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; Thioesterase; condensation domain protein; phosphopantetheine-binding; KEGG: ecv:APECO1_1463 enterobactin synthase multienzyme complex component, ATP-dependent. | 0.754 |
Spro_0342 | hemL | Spro_0342 | Spro_0781 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase. | 0.880 |
Spro_1830 | Spro_0255 | Spro_1830 | Spro_0255 | KEGG: pla:Plav_2905 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aminotransferase class I and II. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.913 |
Spro_1830 | hemL | Spro_1830 | Spro_0781 | KEGG: pla:Plav_2905 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aminotransferase class I and II. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase. | 0.909 |
Spro_2904 | Spro_0255 | Spro_2904 | Spro_0255 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.901 |
Spro_2904 | cysG1 | Spro_2904 | Spro_0817 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.982 |
Spro_2904 | cysG2 | Spro_2904 | Spro_4598 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.982 |
Spro_2904 | hemA | Spro_2904 | Spro_1989 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.831 |
Spro_2904 | hemC | Spro_2904 | Spro_0178 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
Spro_2904 | hemE | Spro_2904 | Spro_0287 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.946 |
Spro_2904 | hemL | Spro_2904 | Spro_0781 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: eca:ECA2989 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase. | 0.805 |
Spro_3427 | Spro_0342 | Spro_3427 | Spro_0342 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; Thioesterase; condensation domain protein; phosphopantetheine-binding; KEGG: ecv:APECO1_1463 enterobactin synthase multienzyme complex component, ATP-dependent. | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase. | 0.754 |