node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0319 | Spro_4784 | Spro_0319 | Spro_4784 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.918 |
Spro_0319 | fmt | Spro_0319 | Spro_4512 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.421 |
Spro_0319 | folD | Spro_0319 | Spro_1168 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.930 |
Spro_0319 | gcvT | Spro_0319 | Spro_3916 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |
Spro_0319 | glyA | Spro_0319 | Spro_3638 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
Spro_0319 | thyA | Spro_0319 | Spro_3821 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.929 |
Spro_3922 | folD | Spro_3922 | Spro_1168 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ypp:YPDSF_0601 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
Spro_3922 | glyA | Spro_3922 | Spro_3638 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ypp:YPDSF_0601 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.464 |
Spro_3922 | purN | Spro_3922 | Spro_3525 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ypp:YPDSF_0601 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.941 |
Spro_4784 | Spro_0319 | Spro_4784 | Spro_0319 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | 0.918 |
Spro_4784 | folD | Spro_4784 | Spro_1168 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
Spro_4784 | gcvT | Spro_4784 | Spro_3916 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
Spro_4784 | glyA | Spro_4784 | Spro_3638 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
Spro_4784 | purH | Spro_4784 | Spro_0293 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: yps:YPTB0300 phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.426 |
Spro_4784 | purN | Spro_4784 | Spro_3525 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.424 |
Spro_4784 | thyA | Spro_4784 | Spro_3821 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.918 |
fmt | Spro_0319 | Spro_4512 | Spro_0319 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | 0.421 |
fmt | folD | Spro_4512 | Spro_1168 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
fmt | gcvT | Spro_4512 | Spro_3916 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.922 |
fmt | glyA | Spro_4512 | Spro_3638 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |