node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0406 | Spro_2020 | Spro_0406 | Spro_2020 | TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.908 |
Spro_0406 | argH | Spro_0406 | Spro_4778 | TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: yen:YE0121 putative argininosuccinate lyase. | 0.913 |
Spro_0406 | purA | Spro_0406 | Spro_0436 | TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.908 |
Spro_1147 | Spro_2020 | Spro_1147 | Spro_2020 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.905 |
Spro_1147 | adk | Spro_1147 | Spro_1139 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.900 |
Spro_1147 | apt | Spro_1147 | Spro_1134 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.907 |
Spro_1147 | purA | Spro_1147 | Spro_0436 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.910 |
Spro_1147 | purH | Spro_1147 | Spro_0293 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | KEGG: yps:YPTB0300 phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.908 |
Spro_1147 | surE | Spro_1147 | Spro_0829 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.914 |
Spro_2020 | Spro_0406 | Spro_2020 | Spro_0406 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. | 0.908 |
Spro_2020 | Spro_1147 | Spro_2020 | Spro_1147 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | 0.905 |
Spro_2020 | adk | Spro_2020 | Spro_1139 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.940 |
Spro_2020 | apt | Spro_2020 | Spro_1134 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |
Spro_2020 | argH | Spro_2020 | Spro_4778 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: yen:YE0121 putative argininosuccinate lyase. | 0.917 |
Spro_2020 | purA | Spro_2020 | Spro_0436 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.982 |
Spro_2020 | purC | Spro_2020 | Spro_3507 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: ypi:YpsIP31758_1249 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.980 |
Spro_2020 | purH | Spro_2020 | Spro_0293 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: yps:YPTB0300 phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.982 |
Spro_2020 | purL | Spro_2020 | Spro_3654 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.990 |
Spro_2020 | surE | Spro_2020 | Spro_0829 | KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Stationary-phase survival protein SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.922 |
adk | Spro_1147 | Spro_1139 | Spro_1147 | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. | 0.900 |