STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
sufSCysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)    
Predicted Functional Partners:
Spro_2181
FeS assembly ATPase SufC; KEGG: yps:YPTB2312 putative ATP-dependent transporter; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase.
 
  
 0.983
Spro_2182
TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: ypi:YpsIP31758_1744 FeS assembly protein SufD.
 
 
 0.978
Spro_2180
TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein; KEGG: yen:YE2171 hypothetical protein.
 
 
 0.966
sufE
Fe-S metabolism associated SufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 0.934
Spro_1681
TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: yen:YE1523 thioredoxin reductase.
 
 
 0.925
selD
Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP.
    
 0.908
Spro_2493
TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: azo:azo0369 probable cysteine desulphurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.904
Spro_4786
O-succinylhomoserine (thiol)-lyase; KEGG: ypi:YpsIP31758_0121 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
     
  0.900
Spro_3626
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.887
Spro_2179
FeS assembly scaffold SufA; TIGRFAM: iron-sulfur cluster assembly accessory protein; FeS assembly scaffold SufA; PFAM: HesB/YadR/YfhF-family protein; KEGG: ypi:YpsIP31758_1741 FeS assembly scaffold SufA; Belongs to the HesB/IscA family.
 
 
 0.742
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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