node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0091 | selD | Spro_0091 | Spro_2720 | TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: yen:YE4130 selenocysteinyl-tRNA-specific translation factor. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.842 |
Spro_0091 | selU | Spro_0091 | Spro_2719 | TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: yen:YE4130 selenocysteinyl-tRNA-specific translation factor. | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.428 |
Spro_2717 | Spro_2721 | Spro_2717 | Spro_2721 | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | 0.527 |
Spro_2717 | selD | Spro_2717 | Spro_2720 | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.797 |
Spro_2717 | selU | Spro_2717 | Spro_2719 | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.790 |
Spro_2717 | topB | Spro_2717 | Spro_2718 | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.784 |
Spro_2721 | Spro_2717 | Spro_2721 | Spro_2717 | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | 0.527 |
Spro_2721 | selD | Spro_2721 | Spro_2720 | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.592 |
Spro_2721 | selU | Spro_2721 | Spro_2719 | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.495 |
Spro_2721 | topB | Spro_2721 | Spro_2718 | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.547 |
mnmC | selU | Spro_3369 | Spro_2719 | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.458 |
mnmC | thiI | Spro_3369 | Spro_1081 | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.430 |
selD | Spro_0091 | Spro_2720 | Spro_0091 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: yen:YE4130 selenocysteinyl-tRNA-specific translation factor. | 0.842 |
selD | Spro_2717 | Spro_2720 | Spro_2717 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | 0.797 |
selD | Spro_2721 | Spro_2720 | Spro_2721 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | 0.592 |
selD | selU | Spro_2720 | Spro_2719 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.966 |
selD | topB | Spro_2720 | Spro_2718 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.797 |
selU | Spro_0091 | Spro_2719 | Spro_0091 | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: yen:YE4130 selenocysteinyl-tRNA-specific translation factor. | 0.428 |
selU | Spro_2717 | Spro_2719 | Spro_2717 | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | PFAM: protein of unknown function DUF1496; KEGG: yen:YE2256 hypothetical protein. | 0.790 |
selU | Spro_2721 | Spro_2719 | Spro_2721 | Rhodanese domain protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | PFAM: nitroreductase; KEGG: ypi:YpsIP31758_1981 nitroreductase family protein. | 0.495 |