STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tri1ADP-ribosyl-(dinitrogen reductase) hydrolase; Immunity component of a contact-dependent interbacterial competition system (also called effector-immunity systems). Acts as an arginine mono-ADP-ribosylhydrolase, mediating the removal of mono-ADP- ribose attached to arginine residues on proteins. De-ADP-ribosylates FtsZ, is able to act on other proteins as well. Neutralizes the toxic activity of cognate toxin Tre1-Sp. Expression of this protein alone in E.coli partially protects the cells against competition by wild-type S.proteamaculans. Neutralizes Tre1-Sp both by occluding its active s [...] (366 aa)    
Predicted Functional Partners:
tre1
PAAR repeat-containing protein; Toxic component of a contact-dependent interbacterial competition system (also called effector-immunity systems). Acts by ADP-ribosylating a number of target proteins in target cells; E.coli target proteins include FtsZ, EFTu, RNase E, Fis, RL9, SucB, and LolD. FtsZ is thought to be the physiologically relevant target as it is ADP- ribosylated on a critical residue. ADP-ribosylation of FtsZ prevents formation of the FtsZ mid-cell ring and inhibits cell division. Overexpression of the whole Tre1 protein or the ART domain in E.coli is toxic; cells elongate [...]
   
 
 0.988
Spro_3016
PFAM: Domain of unknown function DUF1795; KEGG: rso:RSc3427 hypothetical protein.
       0.773
Spro_3015
PFAM: Rhs element Vgr protein; KEGG: bbr:BB0793 hypothetical protein.
       0.743
Spro_1109
PFAM: nitrogen regulatory protein P-II; KEGG: yen:YE3120 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
   
 
 0.702
Spro_3649
PFAM: nitrogen regulatory protein P-II; KEGG: plu:plu3309 nitrogen regulatory protein P-II.1; Belongs to the P(II) protein family.
   
 
 0.702
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.631
Spro_3014
SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: azo:azo3888 putative serine/threonine kinase.
 
     0.581
Spro_3013
PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: pmy:Pmen_2331 ATPase AAA-2 domain protein; Belongs to the ClpA/ClpB family.
  
    0.445
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.