node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP58791.1 | mutM | Ent638_0101 | Ent638_0104 | PFAM: DNA repair protein RadC; KEGG: stm:STM3729 putative DNA repair protein, associated with replication forks; Belongs to the UPF0758 family. YicR subfamily. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.455 |
ABP58791.1 | rpmB | Ent638_0101 | Ent638_0102 | PFAM: DNA repair protein RadC; KEGG: stm:STM3729 putative DNA repair protein, associated with replication forks; Belongs to the UPF0758 family. YicR subfamily. | PFAM: ribosomal protein L28; KEGG: sdy:SDY_4067 50S ribosomal subunit protein L28; Belongs to the bacterial ribosomal protein bL28 family. | 0.519 |
ABP58791.1 | rpmG | Ent638_0101 | Ent638_0103 | PFAM: DNA repair protein RadC; KEGG: stm:STM3729 putative DNA repair protein, associated with replication forks; Belongs to the UPF0758 family. YicR subfamily. | PFAM: ribosomal protein L33; KEGG: eca:ECA0147 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. | 0.448 |
ABP60382.1 | guaA | Ent638_1703 | Ent638_2998 | PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sbo:SBO_1349 putative excinuclease subunit. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.466 |
ABP60382.1 | mutM | Ent638_1703 | Ent638_0104 | PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sbo:SBO_1349 putative excinuclease subunit. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.479 |
ABP60382.1 | polA | Ent638_1703 | Ent638_4102 | PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sbo:SBO_1349 putative excinuclease subunit. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.620 |
coaE | guaA | Ent638_0648 | Ent638_2998 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.450 |
coaE | mutM | Ent638_0648 | Ent638_0104 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.839 |
coaE | nth | Ent638_0648 | Ent638_1815 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.441 |
coaE | polA | Ent638_0648 | Ent638_4102 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.683 |
guaA | ABP60382.1 | Ent638_2998 | Ent638_1703 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sbo:SBO_1349 putative excinuclease subunit. | 0.466 |
guaA | coaE | Ent638_2998 | Ent638_0648 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.450 |
guaA | mutM | Ent638_2998 | Ent638_0104 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.421 |
guaA | polA | Ent638_2998 | Ent638_4102 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.663 |
guaA | rpmG | Ent638_2998 | Ent638_0103 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: ribosomal protein L33; KEGG: eca:ECA0147 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. | 0.560 |
guaA | uvrC | Ent638_2998 | Ent638_2500 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.466 |
guaA | xni | Ent638_2998 | Ent638_3251 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 5'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.497 |
mutM | ABP58791.1 | Ent638_0104 | Ent638_0101 | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | PFAM: DNA repair protein RadC; KEGG: stm:STM3729 putative DNA repair protein, associated with replication forks; Belongs to the UPF0758 family. YicR subfamily. | 0.455 |
mutM | ABP60382.1 | Ent638_0104 | Ent638_1703 | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sbo:SBO_1349 putative excinuclease subunit. | 0.479 |
mutM | coaE | Ent638_0104 | Ent638_0648 | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.839 |