node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP59527.1 | cysG | Ent638_0843 | Ent638_3796 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.906 |
ABP59527.1 | gltX | Ent638_0843 | Ent638_2931 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.439 |
ABP59527.1 | hemA | Ent638_0843 | Ent638_2338 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.875 |
ABP59527.1 | hemC | Ent638_0843 | Ent638_3987 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
ABP59527.1 | hemE | Ent638_0843 | Ent638_0210 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.763 |
ABP59527.1 | hemL | Ent638_0843 | Ent638_0694 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: sbo:SBO_0143 glutamate-1-semialdehyde aminotransferase. | 0.993 |
ABP61003.1 | ABP61004.1 | Ent638_2334 | Ent638_2335 | KEGG: stm:STM1773 putative transcriptional regulator. | PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes. | 0.836 |
ABP61003.1 | hemA | Ent638_2334 | Ent638_2338 | KEGG: stm:STM1773 putative transcriptional regulator. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.669 |
ABP61003.1 | prfA | Ent638_2334 | Ent638_2337 | KEGG: stm:STM1773 putative transcriptional regulator. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.792 |
ABP61003.1 | prmC | Ent638_2334 | Ent638_2336 | KEGG: stm:STM1773 putative transcriptional regulator. | [protein release factor]-glutamine N5-methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.792 |
ABP61004.1 | ABP61003.1 | Ent638_2335 | Ent638_2334 | PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes. | KEGG: stm:STM1773 putative transcriptional regulator. | 0.836 |
ABP61004.1 | hemA | Ent638_2335 | Ent638_2338 | PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.669 |
ABP61004.1 | prfA | Ent638_2335 | Ent638_2337 | PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.808 |
ABP61004.1 | prmC | Ent638_2335 | Ent638_2336 | PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes. | [protein release factor]-glutamine N5-methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.886 |
cysG | ABP59527.1 | Ent638_3796 | Ent638_0843 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sdy:SDY_0501 5-aminolevulinate dehydratase; Belongs to the ALAD family. | 0.906 |
cysG | gltX | Ent638_3796 | Ent638_2931 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.421 |
cysG | hemA | Ent638_3796 | Ent638_2338 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.816 |
cysG | hemC | Ent638_3796 | Ent638_3987 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.993 |
cysG | hemE | Ent638_3796 | Ent638_0210 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.952 |
cysG | hemL | Ent638_3796 | Ent638_0694 | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: sbo:SBO_0143 glutamate-1-semialdehyde aminotransferase. | 0.783 |