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lsrA protein (Enterobacter sp. 638) - STRING interaction network
"lsrA" - Autoinducer 2 import ATP-binding protein LsrA in Enterobacter sp. 638
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
lsrAAutoinducer 2 import ATP-binding protein LsrA; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity) (495 aa)    
Predicted Functional Partners:
lsrC
Autoinducer 2 import system permease protein LsrC; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity) (343 aa)
 
  0.998
lsrD
Autoinducer 2 import system permease protein LsrD; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (By similarity) (327 aa)
 
  0.998
lsrB
Autoinducer 2-binding protein LsrB; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity) (333 aa)
 
  0.995
lsrF
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family (295 aa)
 
   
  0.959
lsrG
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family (97 aa)
 
   
  0.954
lsrK
Autoinducer-2 kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (530 aa)
 
   
  0.912
lsrR
Transcriptional regulator LsrR; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes (By similarity) (323 aa)
 
   
  0.898
ABP58977.1
PFAM- inner-membrane translocator; KEGG- ecs-ECs5072 putative carbohydrate ABC transport system permease (331 aa)
          0.734
ABP62767.1
Ribose ABC transporter membrane protein; PFAM- inner-membrane translocator; KEGG- ssn-SSO_3920 D-ribose high-affinity transport system; Belongs to the binding-protein-dependent transport system permease family (321 aa)
   
  0.729
ABP62727.1
Rhamnose ABC transporter membrane protein; PFAM- inner-membrane translocator; KEGG- ret-RHE_PE00287 probable sugar ABC transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family (334 aa)
        0.681
Your Current Organism:
Enterobacter sp. 638
NCBI taxonomy Id: 399742
Other names: E. sp. 638, Enterobacter sp. 638
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