node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP61448.1 | ABP61504.1 | Ent638_2783 | Ent638_2839 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | 0.762 |
ABP61448.1 | fabR | Ent638_2783 | Ent638_4023 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | 0.624 |
ABP61448.1 | fadR | Ent638_2783 | Ent638_2365 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Transcriptional regulator, GntR family; Multifunctional regulator of fatty acid metabolism. | 0.771 |
ABP61448.1 | metJ | Ent638_2783 | Ent638_4036 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.727 |
ABP61448.1 | mutH | Ent638_2783 | Ent638_3273 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | DNA mismatch repair protein MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.725 |
ABP61448.1 | proQ | Ent638_2783 | Ent638_2401 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.765 |
ABP61448.1 | rraB | Ent638_2783 | Ent638_0460 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.756 |
ABP61448.1 | seqA | Ent638_2783 | Ent638_1202 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.774 |
ABP61448.1 | yihI | Ent638_2783 | Ent638_4100 | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.739 |
ABP61504.1 | ABP61448.1 | Ent638_2839 | Ent638_2783 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | 0.762 |
ABP61504.1 | fabR | Ent638_2839 | Ent638_4023 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | 0.620 |
ABP61504.1 | fadR | Ent638_2839 | Ent638_2365 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Transcriptional regulator, GntR family; Multifunctional regulator of fatty acid metabolism. | 0.710 |
ABP61504.1 | metJ | Ent638_2839 | Ent638_4036 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.747 |
ABP61504.1 | mutH | Ent638_2839 | Ent638_3273 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | DNA mismatch repair protein MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.730 |
ABP61504.1 | proQ | Ent638_2839 | Ent638_2401 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.752 |
ABP61504.1 | rraB | Ent638_2839 | Ent638_0460 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.748 |
ABP61504.1 | seqA | Ent638_2839 | Ent638_1202 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.746 |
ABP61504.1 | yihI | Ent638_2839 | Ent638_4100 | PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 putative cytoplasmic protein. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.784 |
ABP62689.1 | metJ | Ent638_4034 | Ent638_4036 | KEGG: sec:SC3992 aspartokinase II; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.878 |
fabR | ABP61448.1 | Ent638_4023 | Ent638_2783 | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 putative cytoplasmic protein; Belongs to the UPF0352 family. | 0.624 |