STRINGSTRING
ddl protein (Streptococcus equi) - STRING interaction network
"ddl" - D-alanine--D-alanine ligase in Streptococcus equi
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ddlD-alanine--D-alanine ligase; Cell wall formation (348 aa)    
Predicted Functional Partners:
murF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily (461 aa)
 
  0.986
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family (443 aa)
 
  0.982
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids; Belongs to the alanine racemase family (366 aa)
   
  0.979
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation (295 aa)
 
   
  0.954
dltA
D-alanine--D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall; Belongs to the AT [...] (512 aa)
       
  0.927
dltC
D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall (79 aa)
       
  0.914
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1188 aa)
 
     
  0.859
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA); Belongs to the MurCDEF family (457 aa)
   
  0.820
murE
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily (481 aa)
   
  0.797
tuf
Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (404 aa)
         
  0.782
Your Current Organism:
Streptococcus equi
NCBI taxonomy Id: 40041
Other names: ATCC 43079, Animal pyogenes, type A, CCUG 23256, CIP 103228, DSM 20727, LMG 16030, NCIMB 701358, NCTC 4676, S. equi subsp. zooepidemicus, Streptococcus equi, Streptococcus equi subsp. zooepidemicus, Streptococcus equi zooepidemicus, Streptococcus pyogenes animalis, Streptococcus zooepidemicus
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