node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR70466.1 | bioB | Mmwyl1_1538 | Mmwyl1_3457 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.782 |
ABR70466.1 | bioD | Mmwyl1_1538 | Mmwyl1_3453 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.786 |
ABR70466.1 | bioF | Mmwyl1_1538 | Mmwyl1_3456 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.458 |
ABR70466.1 | birA | Mmwyl1_1538 | Mmwyl1_4292 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.525 |
ABR70466.1 | kbl | Mmwyl1_1538 | Mmwyl1_3792 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.458 |
ABR70466.1 | thiE | Mmwyl1_1538 | Mmwyl1_2391 | PFAM: aminotransferase class-III; KEGG: cps:CPS_0099 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.435 |
ABR71975.1 | bioB | Mmwyl1_3065 | Mmwyl1_3457 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.816 |
ABR71975.1 | bioD | Mmwyl1_3065 | Mmwyl1_3453 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.811 |
ABR71975.1 | bioF | Mmwyl1_3065 | Mmwyl1_3456 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.458 |
ABR71975.1 | birA | Mmwyl1_3065 | Mmwyl1_4292 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.525 |
ABR71975.1 | kbl | Mmwyl1_3065 | Mmwyl1_3792 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.458 |
ABR71975.1 | thiE | Mmwyl1_3065 | Mmwyl1_2391 | PFAM: aminotransferase class-III; KEGG: pol:Bpro_0052 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.435 |
ABR72358.1 | bioA | Mmwyl1_3455 | Mmwyl1_3459 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.667 |
ABR72358.1 | bioB | Mmwyl1_3455 | Mmwyl1_3457 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.876 |
ABR72358.1 | bioC | Mmwyl1_3455 | Mmwyl1_3454 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | Methyltransferase type 11; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.979 |
ABR72358.1 | bioD | Mmwyl1_3455 | Mmwyl1_3453 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.932 |
ABR72358.1 | bioF | Mmwyl1_3455 | Mmwyl1_3456 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.989 |
ABR72358.1 | kbl | Mmwyl1_3455 | Mmwyl1_3792 | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.558 |
bioA | ABR72358.1 | Mmwyl1_3459 | Mmwyl1_3455 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Carboxylesterase; PFAM: alpha/beta hydrolase fold; KEGG: pfl:PFL_5691 BioH protein. | 0.667 |
bioA | bioB | Mmwyl1_3459 | Mmwyl1_3457 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.981 |