node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR70888.1 | clpB | Mmwyl1_1964 | Mmwyl1_3609 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.615 |
ABR70888.1 | dnaK | Mmwyl1_1964 | Mmwyl1_3964 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.889 |
ABR70888.1 | ftsH | Mmwyl1_1964 | Mmwyl1_1020 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.458 |
ABR70888.1 | groL | Mmwyl1_1964 | Mmwyl1_2037 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.675 |
ABR70888.1 | groS | Mmwyl1_1964 | Mmwyl1_2036 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.557 |
ABR70888.1 | grpE | Mmwyl1_1964 | Mmwyl1_3965 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.867 |
ABR70888.1 | htpG | Mmwyl1_1964 | Mmwyl1_2370 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.889 |
ABR70888.1 | rapA | Mmwyl1_1964 | Mmwyl1_2892 | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | Helicase domain protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.480 |
ABR72237.1 | clpB | Mmwyl1_3332 | Mmwyl1_3609 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.615 |
ABR72237.1 | dnaK | Mmwyl1_3332 | Mmwyl1_3964 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.932 |
ABR72237.1 | ftsH | Mmwyl1_3332 | Mmwyl1_1020 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.451 |
ABR72237.1 | groL | Mmwyl1_3332 | Mmwyl1_2037 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.699 |
ABR72237.1 | groS | Mmwyl1_3332 | Mmwyl1_2036 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.609 |
ABR72237.1 | grpE | Mmwyl1_3332 | Mmwyl1_3965 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.868 |
ABR72237.1 | htpG | Mmwyl1_3332 | Mmwyl1_2370 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.867 |
ABR72237.1 | rapA | Mmwyl1_3332 | Mmwyl1_2892 | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | Helicase domain protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.480 |
clpB | ABR70888.1 | Mmwyl1_3609 | Mmwyl1_1964 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; KEGG: mca:MCA1727 curved DNA-binding protein. | 0.615 |
clpB | ABR72237.1 | Mmwyl1_3609 | Mmwyl1_3332 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: hch:HCH_00524 DnaJ-class molecular chaperone. | 0.615 |
clpB | dnaJ | Mmwyl1_3609 | Mmwyl1_3963 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.665 |
clpB | dnaK | Mmwyl1_3609 | Mmwyl1_3964 | ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.790 |