node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rpic_0149 | Rpic_1944 | Rpic_0149 | Rpic_1944 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.463 |
Rpic_0149 | Rpic_3658 | Rpic_0149 | Rpic_3658 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | KEGG: rso:RSc0091 probable 5,10-methylenetetrahydrofolate reductase oxidoreductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.984 |
Rpic_0149 | gcvH | Rpic_0149 | Rpic_3488 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.553 |
Rpic_0149 | gcvP | Rpic_0149 | Rpic_3489 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.502 |
Rpic_0149 | gcvT | Rpic_0149 | Rpic_3487 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.936 |
Rpic_0149 | glyA | Rpic_0149 | Rpic_0678 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
Rpic_0149 | purH | Rpic_0149 | Rpic_0380 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | KEGG: rso:RSc0504 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.914 |
Rpic_0149 | purN | Rpic_0149 | Rpic_2722 | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
Rpic_1099 | Rpic_1944 | Rpic_1099 | Rpic_1944 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.980 |
Rpic_1099 | gcvH | Rpic_1099 | Rpic_3488 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.979 |
Rpic_1099 | gcvP | Rpic_1099 | Rpic_3489 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.958 |
Rpic_1099 | gcvT | Rpic_1099 | Rpic_3487 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.957 |
Rpic_1099 | glyA | Rpic_1099 | Rpic_0678 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
Rpic_1944 | Rpic_0149 | Rpic_1944 | Rpic_0149 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | PFAM: homocysteine S-methyltransferase; KEGG: rso:RSc0295 probable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-B12 dependent isozyme) protein. | 0.463 |
Rpic_1944 | Rpic_1099 | Rpic_1944 | Rpic_1099 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. | 0.980 |
Rpic_1944 | Rpic_3658 | Rpic_1944 | Rpic_3658 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | KEGG: rso:RSc0091 probable 5,10-methylenetetrahydrofolate reductase oxidoreductase protein; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.441 |
Rpic_1944 | folD | Rpic_1944 | Rpic_1950 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.557 |
Rpic_1944 | gcvH | Rpic_1944 | Rpic_3488 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.994 |
Rpic_1944 | gcvP | Rpic_1944 | Rpic_3489 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.978 |
Rpic_1944 | gcvT | Rpic_1944 | Rpic_3487 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.993 |