node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO34393.1 | purO | MmarC5_0076 | MmarC5_0283 | TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: mmp:MMP1501 hypothetical protein. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.897 |
ABO34595.1 | ABO34598.1 | MmarC5_0279 | MmarC5_0282 | PFAM: phosphoesterase, RecJ domain protein; RNA binding S1 domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1314 phosphoesterase, RecJ-like:RNA binding S1:OB-fold nucleic acid binding domain related protein. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mmp:MMP1311 ferredoxin. | 0.614 |
ABO34595.1 | purO | MmarC5_0279 | MmarC5_0283 | PFAM: phosphoesterase, RecJ domain protein; RNA binding S1 domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1314 phosphoesterase, RecJ-like:RNA binding S1:OB-fold nucleic acid binding domain related protein. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.844 |
ABO34598.1 | ABO34595.1 | MmarC5_0282 | MmarC5_0279 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mmp:MMP1311 ferredoxin. | PFAM: phosphoesterase, RecJ domain protein; RNA binding S1 domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1314 phosphoesterase, RecJ-like:RNA binding S1:OB-fold nucleic acid binding domain related protein. | 0.614 |
ABO34598.1 | purO | MmarC5_0282 | MmarC5_0283 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mmp:MMP1311 ferredoxin. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.783 |
ABO35518.1 | guaB | MmarC5_1220 | MmarC5_1545 | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.941 |
ABO35518.1 | purA | MmarC5_1220 | MmarC5_0146 | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.991 |
ABO35518.1 | purC | MmarC5_1220 | MmarC5_1067 | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | KEGG: mmp:MMP0540 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.421 |
ABO35518.1 | purO | MmarC5_1220 | MmarC5_0283 | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.900 |
ABO35518.1 | surE | MmarC5_1220 | MmarC5_0542 | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.907 |
guaB | ABO35518.1 | MmarC5_1545 | MmarC5_1220 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | 0.941 |
guaB | purA | MmarC5_1545 | MmarC5_0146 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |
guaB | purC | MmarC5_1545 | MmarC5_1067 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | KEGG: mmp:MMP0540 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.830 |
guaB | purO | MmarC5_1545 | MmarC5_0283 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.919 |
guaB | surE | MmarC5_1545 | MmarC5_0542 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.966 |
purA | ABO35518.1 | MmarC5_0146 | MmarC5_1220 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Cytidine kinase / inosine-guanosine kinase; PFAM: PfkB domain protein; KEGG: mmp:MMP0418 carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | 0.991 |
purA | guaB | MmarC5_0146 | MmarC5_1545 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.998 |
purA | purC | MmarC5_0146 | MmarC5_1067 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | KEGG: mmp:MMP0540 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.916 |
purA | purO | MmarC5_0146 | MmarC5_0283 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.903 |
purA | purP | MmarC5_0146 | MmarC5_0205 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Protein of unknown function DUF1297; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.499 |