node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | MmarC5_1221 | MmarC5_1059 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | 0.991 |
hisA | hisC | MmarC5_1221 | MmarC5_0374 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.988 |
hisA | hisD | MmarC5_1221 | MmarC5_0791 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisE | MmarC5_1221 | MmarC5_1629 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. | 0.982 |
hisA | hisF | MmarC5_1221 | MmarC5_1684 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | MmarC5_1221 | MmarC5_0754 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.997 |
hisA | hisH | MmarC5_1221 | MmarC5_1417 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MmarC5_1221 | MmarC5_1393 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisS | MmarC5_1221 | MmarC5_1794 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | KEGG: mmp:MMP1614 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.725 |
hisA | prs | MmarC5_1221 | MmarC5_1228 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). | 0.674 |
hisB | hisA | MmarC5_1059 | MmarC5_1221 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. | 0.991 |
hisB | hisC | MmarC5_1059 | MmarC5_0374 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class V; aminotransferase, class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.999 |
hisB | hisD | MmarC5_1059 | MmarC5_0791 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | MmarC5_1059 | MmarC5_1629 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. | 0.980 |
hisB | hisF | MmarC5_1059 | MmarC5_1684 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | MmarC5_1059 | MmarC5_0754 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.992 |
hisB | hisH | MmarC5_1059 | MmarC5_1417 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | MmarC5_1059 | MmarC5_1393 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
hisB | hisS | MmarC5_1059 | MmarC5_1794 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | KEGG: mmp:MMP1614 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.593 |
hisB | prs | MmarC5_1059 | MmarC5_1228 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). | 0.465 |