node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO34875.1 | ABO35272.1 | MmarC5_0561 | MmarC5_0966 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | KEGG: mmp:MMP0638 hypothetical protein. | 0.947 |
ABO34875.1 | ABO35556.1 | MmarC5_0561 | MmarC5_1258 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | KEGG: mmp:MMP0380 DNA polymerase family B; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | 0.926 |
ABO34875.1 | ABO35796.1 | MmarC5_0561 | MmarC5_1499 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | AAA family ATPase, CDC48 subfamily; KEGG: mmp:MMP0176 CDC48 cell division cycle protein family member; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase VAT domain protein domain protein; AAA ATPase, central domain protein; cell division protein 48, CDC48, domain 2; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase. | 0.569 |
ABO34875.1 | ABO35853.1 | MmarC5_0561 | MmarC5_1556 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | KEGG: mmp:MMP0122 hypothetical protein. | 0.653 |
ABO34875.1 | fen | MmarC5_0561 | MmarC5_0280 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.722 |
ABO34875.1 | mre11 | MmarC5_0561 | MmarC5_0238 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.944 |
ABO34875.1 | pcn | MmarC5_0561 | MmarC5_1695 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.968 |
ABO34875.1 | radB | MmarC5_0561 | MmarC5_0988 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.929 |
ABO34875.1 | topA | MmarC5_0561 | MmarC5_0781 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.943 |
ABO35272.1 | ABO34875.1 | MmarC5_0966 | MmarC5_0561 | KEGG: mmp:MMP0638 hypothetical protein. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | 0.947 |
ABO35272.1 | ABO35556.1 | MmarC5_0966 | MmarC5_1258 | KEGG: mmp:MMP0638 hypothetical protein. | KEGG: mmp:MMP0380 DNA polymerase family B; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | 0.913 |
ABO35272.1 | ABO35853.1 | MmarC5_0966 | MmarC5_1556 | KEGG: mmp:MMP0638 hypothetical protein. | KEGG: mmp:MMP0122 hypothetical protein. | 0.936 |
ABO35272.1 | fen | MmarC5_0966 | MmarC5_0280 | KEGG: mmp:MMP0638 hypothetical protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.978 |
ABO35272.1 | mre11 | MmarC5_0966 | MmarC5_0238 | KEGG: mmp:MMP0638 hypothetical protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.705 |
ABO35272.1 | pcn | MmarC5_0966 | MmarC5_1695 | KEGG: mmp:MMP0638 hypothetical protein. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.932 |
ABO35272.1 | radB | MmarC5_0966 | MmarC5_0988 | KEGG: mmp:MMP0638 hypothetical protein. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.900 |
ABO35272.1 | top6A | MmarC5_0966 | MmarC5_0141 | KEGG: mmp:MMP0638 hypothetical protein. | Spo11/DNA topoisomerase VI, subunit A-like protein; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.915 |
ABO35272.1 | topA | MmarC5_0966 | MmarC5_0781 | KEGG: mmp:MMP0638 hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.972 |
ABO35556.1 | ABO34875.1 | MmarC5_1258 | MmarC5_0561 | KEGG: mmp:MMP0380 DNA polymerase family B; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. | 0.926 |
ABO35556.1 | ABO35272.1 | MmarC5_1258 | MmarC5_0966 | KEGG: mmp:MMP0380 DNA polymerase family B; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | KEGG: mmp:MMP0638 hypothetical protein. | 0.913 |