STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mptAGTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (315 aa)    
Predicted Functional Partners:
ABO35944.1
Transcriptional regulator, ArsR family; PFAM: regulatory protein, ArsR; SMART: AAA ATPase; KEGG: mmp:MMP0033 LysR family member.
     
 0.972
ABO35741.1
Cyclic phosphodiesterase MptB; KEGG: mmp:MMP0230 hypothetical protein; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region.
  
  
 0.969
ABO35942.1
PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mmp:MMP0035 hypothetical protein.
 
     0.944
tfe
Transcription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
       0.935
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.901
ABO35940.1
KEGG: mmp:MMP0037 hypothetical protein; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region.
       0.868
ABO36100.1
PFAM: pyruvate kinase; KEGG: mmp:MMP1605 pyruvate kinase; Belongs to the pyruvate kinase family.
 
  
  0.849
ABO34657.1
KEGG: mmp:MMP1250 6-pyruvoyl tetrahydropterin synthase.
     
 0.841
ABO35768.1
KEGG: mmp:MMP0227 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein.
  
  
  0.835
ABO34844.1
TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: mmp:MMP1064 RNA-binding region RNP-1 (RNA recognition motif):adenylate cyclase.
    
  0.805
Your Current Organism:
Methanococcus maripaludis C5
NCBI taxonomy Id: 402880
Other names: M. maripaludis C5, Methanococcus maripaludis str. C5, Methanococcus maripaludis strain C5
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