node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Plav_0599 | Plav_0600 | Plav_0599 | Plav_0600 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
Plav_0599 | hisA | Plav_0599 | Plav_1234 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | 0.936 |
Plav_0599 | hisB | Plav_0599 | Plav_1237 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rru:Rru_A3597 imidazoleglycerol-phosphate dehydratase. | 0.952 |
Plav_0599 | hisC | Plav_0599 | Plav_1583 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: bra:BRADO6463 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.906 |
Plav_0599 | hisD | Plav_0599 | Plav_0521 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.937 |
Plav_0599 | hisE | Plav_0599 | Plav_1230 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: swi:Swit_2565 phosphoribosyl-ATP pyrophosphohydrolase. | 0.990 |
Plav_0599 | hisF | Plav_0599 | Plav_1233 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.937 |
Plav_0599 | hisH | Plav_0599 | Plav_1235 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.924 |
Plav_0599 | hisI | Plav_0599 | Plav_2663 | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.929 |
Plav_0600 | Plav_0599 | Plav_0600 | Plav_0599 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | 0.999 |
Plav_0600 | hisA | Plav_0600 | Plav_1234 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | 0.993 |
Plav_0600 | hisB | Plav_0600 | Plav_1237 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rru:Rru_A3597 imidazoleglycerol-phosphate dehydratase. | 0.995 |
Plav_0600 | hisC | Plav_0600 | Plav_1583 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: bra:BRADO6463 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.988 |
Plav_0600 | hisD | Plav_0600 | Plav_0521 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
Plav_0600 | hisE | Plav_0600 | Plav_1230 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: swi:Swit_2565 phosphoribosyl-ATP pyrophosphohydrolase. | 0.998 |
Plav_0600 | hisF | Plav_0600 | Plav_1233 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.995 |
Plav_0600 | hisH | Plav_0600 | Plav_1235 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.995 |
Plav_0600 | hisI | Plav_0600 | Plav_2663 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.995 |
hisA | Plav_0599 | Plav_1234 | Plav_0599 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); KEGG: rpa:RPA1150 ATP phosphoribosyltransferase regulatory subunit. | 0.936 |
hisA | Plav_0600 | Plav_1234 | Plav_0600 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.993 |