node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pmob_1585 | Pmob_1586 | Pmob_1585 | Pmob_1586 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | 0.919 |
Pmob_1585 | Pmob_1591 | Pmob_1585 | Pmob_1591 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: csc:Csac_1143 acetolactate synthase, small subunit. | 0.958 |
Pmob_1585 | Pmob_1592 | Pmob_1585 | Pmob_1592 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: mbu:Mbur_0710 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. | 0.950 |
Pmob_1585 | ilvC | Pmob_1585 | Pmob_1590 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.907 |
Pmob_1585 | ilvD | Pmob_1585 | Pmob_1593 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.984 |
Pmob_1585 | leuA | Pmob_1585 | Pmob_1589 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.977 |
Pmob_1585 | leuC | Pmob_1585 | Pmob_1588 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.991 |
Pmob_1585 | leuC-2 | Pmob_1585 | Pmob_1704 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.960 |
Pmob_1585 | leuD | Pmob_1585 | Pmob_1587 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.990 |
Pmob_1585 | leuD-2 | Pmob_1585 | Pmob_1705 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.960 |
Pmob_1586 | Pmob_1585 | Pmob_1586 | Pmob_1585 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pfu:PF0941 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.919 |
Pmob_1586 | Pmob_1591 | Pmob_1586 | Pmob_1591 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: csc:Csac_1143 acetolactate synthase, small subunit. | 0.989 |
Pmob_1586 | Pmob_1592 | Pmob_1586 | Pmob_1592 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | KEGG: mbu:Mbur_0710 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. | 0.985 |
Pmob_1586 | ilvC | Pmob_1586 | Pmob_1590 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.928 |
Pmob_1586 | ilvD | Pmob_1586 | Pmob_1593 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | KEGG: cth:Cthe_2713 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.914 |
Pmob_1586 | leuA | Pmob_1586 | Pmob_1589 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.911 |
Pmob_1586 | leuC | Pmob_1586 | Pmob_1588 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
Pmob_1586 | leuC-2 | Pmob_1586 | Pmob_1704 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.997 |
Pmob_1586 | leuD | Pmob_1586 | Pmob_1587 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.997 |
Pmob_1586 | leuD-2 | Pmob_1586 | Pmob_1705 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pfu:PF0940 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.973 |