node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pmob_0318 | folD | Pmob_0318 | Pmob_1757 | PFAM: methylenetetrahydrofolate reductase; KEGG: fno:Fnod_1279 methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.928 |
Pmob_0318 | gcvT | Pmob_0318 | Pmob_1912 | PFAM: methylenetetrahydrofolate reductase; KEGG: fno:Fnod_1279 methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
Pmob_0318 | glyA | Pmob_0318 | Pmob_1468 | PFAM: methylenetetrahydrofolate reductase; KEGG: fno:Fnod_1279 methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
Pmob_1031 | Pmob_1660 | Pmob_1031 | Pmob_1660 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | 0.903 |
Pmob_1031 | fhs | Pmob_1031 | Pmob_1756 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.919 |
Pmob_1031 | fmt | Pmob_1031 | Pmob_0050 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.910 |
Pmob_1031 | folD | Pmob_1031 | Pmob_1757 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
Pmob_1031 | gcvT | Pmob_1031 | Pmob_1912 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.921 |
Pmob_1031 | purH | Pmob_1031 | Pmob_1777 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | KEGG: ctc:CTC01962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.903 |
Pmob_1031 | purN | Pmob_1031 | Pmob_1778 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
Pmob_1660 | Pmob_1031 | Pmob_1660 | Pmob_1031 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | 0.903 |
Pmob_1660 | fhs | Pmob_1660 | Pmob_1756 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.975 |
Pmob_1660 | folD | Pmob_1660 | Pmob_1757 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.960 |
Pmob_1660 | gcvT | Pmob_1660 | Pmob_1912 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
Pmob_1660 | glyA | Pmob_1660 | Pmob_1468 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |
Pmob_1660 | purD | Pmob_1660 | Pmob_1775 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | KEGG: cpr:CPR_0676 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.929 |
Pmob_1660 | purH | Pmob_1660 | Pmob_1777 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | KEGG: ctc:CTC01962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.927 |
Pmob_1660 | purN | Pmob_1660 | Pmob_1778 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.992 |
fhs | Pmob_1031 | Pmob_1756 | Pmob_1031 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. | 0.919 |
fhs | Pmob_1660 | Pmob_1756 | Pmob_1660 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. | 0.975 |