node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gbem_0049 | bioF | Gbem_0049 | Gbem_0831 | 2-amino-3-ketobutyrate--coenzyme A ligase. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.906 |
Gbem_0049 | gcvP1 | Gbem_0049 | Gbem_0397 | 2-amino-3-ketobutyrate--coenzyme A ligase. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.917 |
Gbem_0049 | gcvP2 | Gbem_0049 | Gbem_0398 | 2-amino-3-ketobutyrate--coenzyme A ligase. | Glycine cleavage system P protein, subunit 2. | 0.918 |
Gbem_0049 | gcvT | Gbem_0049 | Gbem_0395 | 2-amino-3-ketobutyrate--coenzyme A ligase. | Glycine cleavage system T protein. | 0.578 |
Gbem_0049 | glyA | Gbem_0049 | Gbem_3102 | 2-amino-3-ketobutyrate--coenzyme A ligase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
Gbem_0049 | ltaA | Gbem_0049 | Gbem_3418 | 2-amino-3-ketobutyrate--coenzyme A ligase. | L-allo-threonine aldolase, stereospecific. | 0.911 |
Gbem_0049 | ltaE | Gbem_0049 | Gbem_1928 | 2-amino-3-ketobutyrate--coenzyme A ligase. | L-threonine aldolase, low-specificity; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.911 |
bioF | Gbem_0049 | Gbem_0831 | Gbem_0049 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 2-amino-3-ketobutyrate--coenzyme A ligase. | 0.906 |
bioF | gcvP1 | Gbem_0831 | Gbem_0397 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.917 |
bioF | gcvP2 | Gbem_0831 | Gbem_0398 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Glycine cleavage system P protein, subunit 2. | 0.918 |
bioF | gcvT | Gbem_0831 | Gbem_0395 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Glycine cleavage system T protein. | 0.578 |
bioF | glyA | Gbem_0831 | Gbem_3102 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
bioF | ltaA | Gbem_0831 | Gbem_3418 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | L-allo-threonine aldolase, stereospecific. | 0.911 |
bioF | ltaE | Gbem_0831 | Gbem_1928 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | L-threonine aldolase, low-specificity; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.911 |
gcvH | gcvP1 | Gbem_0396 | Gbem_0397 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
gcvH | gcvP2 | Gbem_0396 | Gbem_0398 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 2. | 0.999 |
gcvH | gcvT | Gbem_0396 | Gbem_0395 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein. | 0.999 |
gcvH | glyA | Gbem_0396 | Gbem_3102 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
gcvH | larG | Gbem_0396 | Gbem_1563 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoyl carrier protein LarG; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.908 |
gcvH | lpdA-1 | Gbem_0396 | Gbem_0706 | Glycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase. | 0.975 |