node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABS24539.1 | ABS25422.1 | Anae109_0323 | Anae109_1214 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | 0.475 |
ABS24539.1 | hisA | Anae109_0323 | Anae109_0756 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | PFAM: histidine biosynthesis protein; KEGG: ade:Adeh_0715 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.929 |
ABS24539.1 | hisB | Anae109_0323 | Anae109_0754 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: ade:Adeh_0713 imidazoleglycerol-phosphate dehydratase. | 0.998 |
ABS24539.1 | hisC | Anae109_0323 | Anae109_2310 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mxa:MXAN_4038 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.907 |
ABS24539.1 | hisD | Anae109_0323 | Anae109_0753 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
ABS24539.1 | hisF | Anae109_0323 | Anae109_0757 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.944 |
ABS24539.1 | hisG | Anae109_0323 | Anae109_4216 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.922 |
ABS24539.1 | hisH | Anae109_0323 | Anae109_0755 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.949 |
ABS24539.1 | hisZ | Anae109_0323 | Anae109_2505 | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.837 |
ABS25422.1 | ABS24539.1 | Anae109_1214 | Anae109_0323 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | PFAM: aminotransferase class I and II; KEGG: ade:Adeh_4103 aminotransferase, class I and II. | 0.475 |
ABS25422.1 | hisA | Anae109_1214 | Anae109_0756 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | PFAM: histidine biosynthesis protein; KEGG: ade:Adeh_0715 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.639 |
ABS25422.1 | hisB | Anae109_1214 | Anae109_0754 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: ade:Adeh_0713 imidazoleglycerol-phosphate dehydratase. | 0.641 |
ABS25422.1 | hisC | Anae109_1214 | Anae109_2310 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mxa:MXAN_4038 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.475 |
ABS25422.1 | hisD | Anae109_1214 | Anae109_0753 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.556 |
ABS25422.1 | hisF | Anae109_1214 | Anae109_0757 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.732 |
ABS25422.1 | hisG | Anae109_1214 | Anae109_4216 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.455 |
ABS25422.1 | hisH | Anae109_1214 | Anae109_0755 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.676 |
ABS25422.1 | hisZ | Anae109_1214 | Anae109_2505 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ade:Adeh_1167 HAD-superfamily subfamily IB, PSPase-like. | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.531 |
guaA | hisA | Anae109_1525 | Anae109_0756 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: histidine biosynthesis protein; KEGG: ade:Adeh_0715 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.783 |
guaA | hisF | Anae109_1525 | Anae109_0757 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.431 |