node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SACE_2696 | SACE_2875 | SACE_2696 | SACE_2875 | Putative non-ribosomal peptide synthetase. | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | 0.997 |
SACE_2696 | SACE_4124 | SACE_2696 | SACE_4124 | Putative non-ribosomal peptide synthetase. | Non-ribosomal peptide synthetase. | 0.973 |
SACE_2696 | SACE_4138 | SACE_2696 | SACE_4138 | Putative non-ribosomal peptide synthetase. | Type I PKS modular polyketide synthas. | 0.998 |
SACE_2696 | SACE_4287 | SACE_2696 | SACE_4287 | Putative non-ribosomal peptide synthetase. | Putative non-ribosomal peptide synthetase. | 0.905 |
SACE_2696 | eryAII | SACE_2696 | SACE_0723 | Putative non-ribosomal peptide synthetase. | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | 0.995 |
SACE_2696 | eryAIII | SACE_2696 | SACE_0724 | Putative non-ribosomal peptide synthetase. | EryAIII Erythromycin polyketide synthase modules 5 and 6. | 0.996 |
SACE_2696 | eryCII | SACE_2696 | SACE_0725 | Putative non-ribosomal peptide synthetase. | TDP-4-keto-6-deoxy-glucose 3,4-isomerase; Involved in the erythromycin biosynthesis pathway. Acts by forming a complex and stabilizing the desosaminyl transferase EryCIII. | 0.799 |
SACE_2696 | eryK | SACE_2696 | SACE_0713 | Putative non-ribosomal peptide synthetase. | Cytochrome P450 Erythromycin B/D C-12 hydroxylase; Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme. | 0.799 |
SACE_2875 | SACE_2696 | SACE_2875 | SACE_2696 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Putative non-ribosomal peptide synthetase. | 0.997 |
SACE_2875 | SACE_4124 | SACE_2875 | SACE_4124 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Non-ribosomal peptide synthetase. | 0.994 |
SACE_2875 | SACE_4138 | SACE_2875 | SACE_4138 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Type I PKS modular polyketide synthas. | 0.995 |
SACE_2875 | SACE_4287 | SACE_2875 | SACE_4287 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Putative non-ribosomal peptide synthetase. | 0.993 |
SACE_2875 | eryAII | SACE_2875 | SACE_0723 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | 0.992 |
SACE_2875 | eryAIII | SACE_2875 | SACE_0724 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | EryAIII Erythromycin polyketide synthase modules 5 and 6. | 0.991 |
SACE_2875 | eryCII | SACE_2875 | SACE_0725 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | TDP-4-keto-6-deoxy-glucose 3,4-isomerase; Involved in the erythromycin biosynthesis pathway. Acts by forming a complex and stabilizing the desosaminyl transferase EryCIII. | 0.889 |
SACE_2875 | eryCIII | SACE_2875 | SACE_0726 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B; Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway. | 0.656 |
SACE_2875 | eryG | SACE_2875 | SACE_0728 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Erythromycin C methlytransferase; S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway. Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. Can also methylate the precursor erythromycin D, forming erythromycin B. | 0.562 |
SACE_2875 | eryK | SACE_2875 | SACE_0713 | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | Cytochrome P450 Erythromycin B/D C-12 hydroxylase; Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme. | 0.856 |
SACE_4124 | SACE_2696 | SACE_4124 | SACE_2696 | Non-ribosomal peptide synthetase. | Putative non-ribosomal peptide synthetase. | 0.973 |
SACE_4124 | SACE_2875 | SACE_4124 | SACE_2875 | Non-ribosomal peptide synthetase. | Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. | 0.994 |