STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eryCIIIGlycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B; Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway. (421 aa)    
Predicted Functional Partners:
eryCII
TDP-4-keto-6-deoxy-glucose 3,4-isomerase; Involved in the erythromycin biosynthesis pathway. Acts by forming a complex and stabilizing the desosaminyl transferase EryCIII.
  
 0.999
eryG
Erythromycin C methlytransferase; S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway. Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. Can also methylate the precursor erythromycin D, forming erythromycin B.
 
  
 0.989
eryAIII
EryAIII Erythromycin polyketide synthase modules 5 and 6.
 
  
 0.959
eryK
Cytochrome P450 Erythromycin B/D C-12 hydroxylase; Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.
  
 
 0.945
eryCVI
TDP-desosamine-N-dimethyltransferase.
 
  
 0.940
eryAII
EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2.
 
  
 0.913
eryBV
6-DEB TDP-mycarosyl glycosyltransferase.
  
  
 
0.907
eryBII
TDP-4-keto-6-deoxyhexose 2,3-reductase.
     
 0.875
eryBIV
dTDP-4-keto-6-deoxy-L-hexose 4-reductase.
 
  
  0.853
eryBVI
NDP-4-keto-6-deoxy-glucose 2,3-dehydratase.
 
   
 0.800
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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