node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eryAI | eryAII | SACE_0721 | SACE_0723 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | 0.959 |
eryAI | eryAIII | SACE_0721 | SACE_0724 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | EryAIII Erythromycin polyketide synthase modules 5 and 6. | 0.956 |
eryAI | eryCII | SACE_0721 | SACE_0725 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | TDP-4-keto-6-deoxy-glucose 3,4-isomerase; Involved in the erythromycin biosynthesis pathway. Acts by forming a complex and stabilizing the desosaminyl transferase EryCIII. | 0.588 |
eryAI | eryCIII | SACE_0721 | SACE_0726 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B; Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway. | 0.745 |
eryAI | eryCV | SACE_0721 | SACE_0715 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | EryCV NDP-4,6-dideoxyhexose 3,4-enoyl reductase. | 0.608 |
eryAI | eryCVI | SACE_0721 | SACE_0718 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | TDP-desosamine-N-dimethyltransferase. | 0.674 |
eryAI | eryG | SACE_0721 | SACE_0728 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | Erythromycin C methlytransferase; S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway. Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. Can also methylate the precursor erythromycin D, forming erythromycin B. | 0.732 |
eryAI | eryK | SACE_0721 | SACE_0713 | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | Cytochrome P450 Erythromycin B/D C-12 hydroxylase; Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme. | 0.681 |
eryAII | eryAI | SACE_0723 | SACE_0721 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | 0.959 |
eryAII | eryAIII | SACE_0723 | SACE_0724 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | EryAIII Erythromycin polyketide synthase modules 5 and 6. | 0.999 |
eryAII | eryBII | SACE_0723 | SACE_0727 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | TDP-4-keto-6-deoxyhexose 2,3-reductase. | 0.804 |
eryAII | eryCII | SACE_0723 | SACE_0725 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | TDP-4-keto-6-deoxy-glucose 3,4-isomerase; Involved in the erythromycin biosynthesis pathway. Acts by forming a complex and stabilizing the desosaminyl transferase EryCIII. | 0.961 |
eryAII | eryCIII | SACE_0723 | SACE_0726 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B; Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway. | 0.913 |
eryAII | eryCV | SACE_0723 | SACE_0715 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | EryCV NDP-4,6-dideoxyhexose 3,4-enoyl reductase. | 0.568 |
eryAII | eryG | SACE_0723 | SACE_0728 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | Erythromycin C methlytransferase; S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes the last step in the erythromycin biosynthesis pathway. Methylates the position 3 of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. Can also methylate the precursor erythromycin D, forming erythromycin B. | 0.830 |
eryAII | eryK | SACE_0723 | SACE_0713 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | Cytochrome P450 Erythromycin B/D C-12 hydroxylase; Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme. | 0.835 |
eryAII | metK-2 | SACE_0723 | SACE_3900 | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | Putative S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.479 |
eryAIII | eryAI | SACE_0724 | SACE_0721 | EryAIII Erythromycin polyketide synthase modules 5 and 6. | EryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. | 0.956 |
eryAIII | eryAII | SACE_0724 | SACE_0723 | EryAIII Erythromycin polyketide synthase modules 5 and 6. | EryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. | 0.999 |
eryAIII | eryBII | SACE_0724 | SACE_0727 | EryAIII Erythromycin polyketide synthase modules 5 and 6. | TDP-4-keto-6-deoxyhexose 2,3-reductase. | 0.774 |