node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SACE_2691 | SACE_4497 | SACE_2691 | SACE_4497 | methionyl-tRNA formyltransferase. | Probable methenyltetrahydrofolate cyclohydrolase. | 0.913 |
SACE_2691 | fmt | SACE_2691 | SACE_2113 | methionyl-tRNA formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
SACE_2691 | folD | SACE_2691 | SACE_4498 | methionyl-tRNA formyltransferase. | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
SACE_2691 | glyA2 | SACE_2691 | SACE_4495 | methionyl-tRNA formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
SACE_2691 | glyA2-2 | SACE_2691 | SACE_5702 | methionyl-tRNA formyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
SACE_2691 | purH | SACE_2691 | SACE_6664 | methionyl-tRNA formyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.403 |
SACE_2691 | purN | SACE_2691 | SACE_6665 | methionyl-tRNA formyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.939 |
SACE_4497 | SACE_2691 | SACE_4497 | SACE_2691 | Probable methenyltetrahydrofolate cyclohydrolase. | methionyl-tRNA formyltransferase. | 0.913 |
SACE_4497 | fhs | SACE_4497 | SACE_5619 | Probable methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.947 |
SACE_4497 | fmt | SACE_4497 | SACE_2113 | Probable methenyltetrahydrofolate cyclohydrolase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.913 |
SACE_4497 | folD | SACE_4497 | SACE_4498 | Probable methenyltetrahydrofolate cyclohydrolase. | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.982 |
SACE_4497 | purH | SACE_4497 | SACE_6664 | Probable methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.911 |
SACE_4497 | purN | SACE_4497 | SACE_6665 | Probable methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |
SACE_4497 | purU | SACE_4497 | SACE_6982 | Probable methenyltetrahydrofolate cyclohydrolase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |
SACE_4497 | purU-2 | SACE_4497 | SACE_4502 | Probable methenyltetrahydrofolate cyclohydrolase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |
fhs | SACE_4497 | SACE_5619 | SACE_4497 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Probable methenyltetrahydrofolate cyclohydrolase. | 0.947 |
fhs | folD | SACE_5619 | SACE_4498 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA2 | SACE_5619 | SACE_4495 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
fhs | glyA2-2 | SACE_5619 | SACE_5702 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
fhs | purH | SACE_5619 | SACE_6664 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.982 |