node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR53963.1 | ABR54198.1 | Mevan_0048 | Mevan_0289 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.988 |
ABR53963.1 | ABR54478.1 | Mevan_0048 | Mevan_0571 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.998 |
ABR53963.1 | ABR55001.1 | Mevan_0048 | Mevan_1101 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | TIGRFAM: siroheme synthase; KEGG: mmp:MMP0089 precorrin-2 oxidase / ferrochelatase. | 0.640 |
ABR53963.1 | ABR55278.1 | Mevan_0048 | Mevan_1381 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.998 |
ABR53963.1 | cbiX | Mevan_0048 | Mevan_1169 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.437 |
ABR53963.1 | cobS | Mevan_0048 | Mevan_0251 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.502 |
ABR53963.1 | hemA | Mevan_0048 | Mevan_1100 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.988 |
ABR53963.1 | hemL | Mevan_0048 | Mevan_1237 | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mmp:MMP0224 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.944 |
ABR54198.1 | ABR53963.1 | Mevan_0289 | Mevan_0048 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | 0.988 |
ABR54198.1 | ABR54478.1 | Mevan_0289 | Mevan_0571 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.868 |
ABR54198.1 | ABR55001.1 | Mevan_0289 | Mevan_1101 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: siroheme synthase; KEGG: mmp:MMP0089 precorrin-2 oxidase / ferrochelatase. | 0.993 |
ABR54198.1 | ABR55278.1 | Mevan_0289 | Mevan_1381 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.997 |
ABR54198.1 | cbiX | Mevan_0289 | Mevan_1169 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.877 |
ABR54198.1 | cobS | Mevan_0289 | Mevan_0251 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.673 |
ABR54198.1 | hemA | Mevan_0289 | Mevan_1100 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.795 |
ABR54198.1 | hemL | Mevan_0289 | Mevan_1237 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: mmp:MMP0224 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.673 |
ABR54478.1 | ABR53963.1 | Mevan_0571 | Mevan_0048 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; KEGG: mmp:MMP0872 porphobilinogen deaminase. | 0.998 |
ABR54478.1 | ABR54198.1 | Mevan_0571 | Mevan_0289 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mmp:MMP0966 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.868 |
ABR54478.1 | ABR55001.1 | Mevan_0571 | Mevan_1101 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: siroheme synthase; KEGG: mmp:MMP0089 precorrin-2 oxidase / ferrochelatase. | 0.416 |
ABR54478.1 | ABR55278.1 | Mevan_0571 | Mevan_1381 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mmp:MMP1258 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.959 |