node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR54660.1 | ABR55088.1 | Mevan_0754 | Mevan_1190 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; TGS domain protein; KEGG: mmp:MMP1443 GTP1/OBG family:ATP/GTP-binding site motif A (P-loop):TGS domain:small GTP-binding protein domain. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.510 |
ABR54660.1 | dphB | Mevan_0754 | Mevan_1459 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; TGS domain protein; KEGG: mmp:MMP1443 GTP1/OBG family:ATP/GTP-binding site motif A (P-loop):TGS domain:small GTP-binding protein domain. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.667 |
ABR54660.1 | eif2b | Mevan_0754 | Mevan_1308 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; TGS domain protein; KEGG: mmp:MMP1443 GTP1/OBG family:ATP/GTP-binding site motif A (P-loop):TGS domain:small GTP-binding protein domain. | Putative translation initiation factor aIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.622 |
ABR54660.1 | fusA | Mevan_0754 | Mevan_0679 | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; TGS domain protein; KEGG: mmp:MMP1443 GTP1/OBG family:ATP/GTP-binding site motif A (P-loop):TGS domain:small GTP-binding protein domain. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...] | 0.462 |
ABR55088.1 | ABR54660.1 | Mevan_1190 | Mevan_0754 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; TGS domain protein; KEGG: mmp:MMP1443 GTP1/OBG family:ATP/GTP-binding site motif A (P-loop):TGS domain:small GTP-binding protein domain. | 0.510 |
ABR55088.1 | ABR55231.1 | Mevan_1190 | Mevan_1334 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein. | 0.443 |
ABR55088.1 | ABR55250.1 | Mevan_1190 | Mevan_1353 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mmp:MMP0343 hypothetical protein. | 0.665 |
ABR55088.1 | dphB | Mevan_1190 | Mevan_1459 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.927 |
ABR55088.1 | eif2b | Mevan_1190 | Mevan_1308 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative translation initiation factor aIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.458 |
ABR55088.1 | fusA | Mevan_1190 | Mevan_0679 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...] | 0.991 |
ABR55088.1 | pelA | Mevan_1190 | Mevan_1097 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.464 |
ABR55140.1 | dacZ | Mevan_1243 | Mevan_0788 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: mmp:MMP0230 hypothetical protein. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.629 |
ABR55140.1 | dphB | Mevan_1243 | Mevan_1459 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: mmp:MMP0230 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.622 |
ABR55140.1 | hisC | Mevan_1243 | Mevan_0531 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: mmp:MMP0230 hypothetical protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. | 0.624 |
ABR55231.1 | ABR55088.1 | Mevan_1334 | Mevan_1190 | PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.443 |
ABR55231.1 | dphB | Mevan_1334 | Mevan_1459 | PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.630 |
ABR55231.1 | eif2b | Mevan_1334 | Mevan_1308 | PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein. | Putative translation initiation factor aIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.483 |
ABR55231.1 | pelA | Mevan_1334 | Mevan_1097 | PFAM: protein of unknown function Met10; KEGG: mmp:MMP0323 hypothetical protein. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.456 |
ABR55250.1 | ABR55088.1 | Mevan_1353 | Mevan_1190 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mmp:MMP0343 hypothetical protein. | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.665 |
ABR55250.1 | dphB | Mevan_1353 | Mevan_1459 | TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: mmp:MMP0343 hypothetical protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.790 |