node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR54293.1 | ABR54338.1 | Mevan_0385 | Mevan_0430 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | 0.863 |
ABR54293.1 | ABR55046.1 | Mevan_0385 | Mevan_1147 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | 0.900 |
ABR54293.1 | ABR55434.1 | Mevan_0385 | Mevan_1542 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. | 0.936 |
ABR54293.1 | ABR55435.1 | Mevan_0385 | Mevan_1543 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. | 0.955 |
ABR54293.1 | ABR55585.1 | Mevan_0385 | Mevan_1693 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.867 |
ABR54293.1 | hacB | Mevan_0385 | Mevan_1368 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.843 |
ABR54293.1 | ilvC | Mevan_0385 | Mevan_1538 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.788 |
ABR54293.1 | leuC | Mevan_0385 | Mevan_0471 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.969 |
ABR54293.1 | leuC-2 | Mevan_0385 | Mevan_0789 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.838 |
ABR54293.1 | leuD | Mevan_0385 | Mevan_1141 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.967 |
ABR54338.1 | ABR54293.1 | Mevan_0430 | Mevan_0385 | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.863 |
ABR54338.1 | ABR55585.1 | Mevan_0430 | Mevan_1693 | TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mmp:MMP1105 succinate-CoA ligase (ADP-forming), beta chain. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.857 |
ABR55046.1 | ABR54293.1 | Mevan_1147 | Mevan_0385 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.900 |
ABR55046.1 | ABR55434.1 | Mevan_1147 | Mevan_1542 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. | 0.998 |
ABR55046.1 | ABR55435.1 | Mevan_1147 | Mevan_1543 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. | 0.917 |
ABR55046.1 | ABR55585.1 | Mevan_1147 | Mevan_1693 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. | 0.952 |
ABR55046.1 | hacB | Mevan_1147 | Mevan_1368 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.598 |
ABR55046.1 | ilvC | Mevan_1147 | Mevan_1538 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
ABR55046.1 | leuC | Mevan_1147 | Mevan_0471 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.520 |
ABR55046.1 | leuC-2 | Mevan_1147 | Mevan_0789 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.520 |