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FEN1 protein (Solanum lycopersicum) - STRING interaction network
"FEN1" - Flap endonuclease 1 in Solanum lycopersicum
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FEN1Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (382 aa)    
Predicted Functional Partners:
Solyc02g091120.2.1
DNA LIGASE 6 (1473 aa)
   
 
  0.996
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (264 aa)
     
 
  0.993
101262281
annotation not available (802 aa)
   
 
  0.986
MSH2
Uncharacterized protein; Component of the post-replicative DNA mismatch repair system (MMR) (943 aa)
   
 
  0.981
101245268
Uncharacterized protein; Homolog of X-ray repair cross complementing 3 (XRCC3) (285 aa)
   
 
  0.969
101256637
DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (1086 aa)
     
 
  0.968
101264414
Transducin family protein / WD-40 repeat family protein (989 aa)
     
 
  0.961
101267455
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (527 aa)
   
   
  0.960
Solyc11g040120.1.1
DNA helicase; Minichromosome maintenance (MCM2/3/5) family protein; Belongs to the MCM family (860 aa)
   
 
  0.952
101249010
Uncharacterized protein; Cell division cycle 45 (595 aa)
     
   
  0.952
Your Current Organism:
Solanum lycopersicum
NCBI taxonomy Id: 4081
Other names: Lycopersicon esculentum, Lycopersicon esculentum Mill., Lycopersicon esculentum var. esculentum, S. lycopersicum, Solanum esculentum, Solanum esculentum Dunal, Solanum lycopersicum, Solanum lycopersicum L., tomato
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